CAJ | 학술논문

目的研究血清尿酸(serum uric acid,SUA)水平与民航飞行员冠状动脉粥样硬化性心脏病(冠心病)的相关性.方法对46例疑似冠心病的民航飞行员行冠状动脉造影,并采集空腹静脉血样测定血清尿酸、血糖及血脂水平,分析上述生化指标、病史、年龄与冠心病的相关性.结果经冠状动脉造影,18例(39.1%)确诊冠心病,列为冠心病组;28例(60.9%)冠状动脉造影正常或病变轻微,列为非冠心病组.两组间年龄差异有统计学意义(t=2.187,P＜0.05);合并高血压、低高密度脂蛋白胆固醇血症及高尿酸血症方面差异有统计学意义(P＜0.05);但在合并糖尿病、吸烟、高胆固醇血症、高甘油三酯血症、高低密度脂蛋白胆固醇血症方面差异无统计学意义(P＞0.05);冠心病组飞行员平均血清尿酸水平为(430.58±89.10) μmol/L,明显高于非冠心病组的(341.70±78.11) μmol/L,差异有统计学意义(t=3.565,P＜0.01).精确Logistic检验结果显示SUA是冠心病的独立危险因素.结论高尿酸血症可能是引起飞行员冠心病的独立危险因素.
목적 연구혈청뇨산(serum uric acid,SUA)수평여민항비행원관상동맥죽양경화성심장병(관심병)적상관성.방법 대46례의사관심병적민항비행원행관상동맥조영,병채집공복정맥혈양측정혈청뇨산、혈당급혈지수평,분석상술생화지표、병사、년령여관심병적상관성.결과 경관상동맥조영,18례(39.1%)학진관심병,렬위관심병조;28례(60.9%)관상동맥조영정상혹병변경미,렬위비관심병조.량조간년령차이유통계학의의(t=2.187,P＜0.05);합병고혈압、저고밀도지단백담고순혈증급고뇨산혈증방면차이유통계학의의(P＜0.05);단재합병당뇨병、흡연、고담고순혈증、고감유삼지혈증、고저밀도지단백담고순혈증방면차이무통계학의의(P＞0.05);관심병조비행원평균혈청뇨산수평위(430.58±89.10) μmol/L,명현고우비관심병조적(341.70±78.11) μmol/L,차이유통계학의의(t=3.565,P＜0.01).정학Logistic검험결과현시SUA시관심병적독립위험인소.결론 고뇨산혈증가능시인기비행원관심병적독립위험인소.
Objective To investigate the correlation between the serum uric acid (SUA) level and the coronary heart disease (CHD) events in Chinese civil pilots. Methods Fasting blood samples were collected from 46 civil pilots who were likely diagnosed as CHD, and coronary arteriongraphy was conducted for final diagnosis in these subjects. The SUA levels, fasting blood glucose and blood lipid profile were measured and the correlation between CHD events and the above-mentioned biochemical results, history and age were statistically analyzed. Results Eighteen patients (39.1%) were diagnosed as CHD, while 28(60.9%) had no or minor abnormalities determined by coronary arteriongraphy, so as to be classified into CHD or non-CHD group respectively. The differences on age and the association of hypertension, low high density lipoprotein concentrations and hyperuricemia were significant between two groups (P<0.05), but on the association of diabetes, smoking, high cholesterol, high triglyceride and high low density lipoprotein concentrations (P>0.05). The mean SUA level in CHD group was significantly higher than that in non-CHD group [(430.58±89.10) μmol/L vs (341.70±78.11) μmol/L] (t=3.565, P<0.01). Furthermore, the exact Logistic regression indicated that the SUA concentration was the independent risk factor against CHD incidence. Conclusion The elevation of SUA might be an independent risk factor that induced CHD in pilot.