CAJ | 학술논문

目的探讨结外弥漫性大B细胞淋巴瘤的临床特征和治疗结果.方法回顾性分析2000--2006年期间收治的99例结外弥漫性大B细胞淋巴瘤(DLBCL),所有病例经过病理和免疫组化确诊.胃肠道原发32例,原发中枢神经系统和睾丸共14例,其余部位53例.结果结外DLBCL的临床特点主要表现为高龄、男性略多见、全身症状少见、Ⅰ～Ⅱ期多见、一般状态较好、国际预后指数评分多为中低分.全组5年总生存率为78.9%,原发胃肠道、原发中枢神经系统和睾丸、其他原发部位的5年总生存率分别为82.5%、37.0%、74.6%.全组病例单因素预后分析显示PS评分、结外受侵>1个及国际预后指数评分对5年总生存率有影响.结论结外DLBCL为一组异质性疾病,预后良好,但原发于中枢神经系统和睾丸部位的病例预后可能较差.
목적 탐토결외미만성대B세포림파류적림상특정화치료결과.방법 회고성분석2000--2006년기간수치적99례결외미만성대B세포림파류(DLBCL),소유병례경과병리화면역조화학진.위장도원발32례,원발중추신경계통화고환공14례,기여부위53례.결과 결외DLBCL적림상특점주요표현위고령、남성략다견、전신증상소견、Ⅰ～Ⅱ기다견、일반상태교호、국제예후지수평분다위중저분.전조5년총생존솔위78.9%,원발위장도、원발중추신경계통화고환、기타원발부위적5년총생존솔분별위82.5%、37.0%、74.6%.전조병례단인소예후분석현시PS평분、결외수침>1개급국제예후지수평분대5년총생존솔유영향.결론 결외DLBCL위일조이질성질병,예후량호,단원발우중추신경계통화고환부위적병례예후가능교차.
Objective To analyze the clinical features and treatment outcomes of extranodal diffuse large B-cell lymphoma(DLBCL). Methods Ninety-nine consecutively diagnosed patients with extranodal DLBCL were reviewed. All patients were confirmed by a combination of morphologic and immunohistochemi-cal evaluation. The primary sites of extranodal DLBCL were the gastrointestine(n = 32) ,central nerve system (CNS)/testis(n=14) ,and other sites (n = 53). Results Extranodal DLBCL was characterized by a pre-dominance in old males,less frequency of B symptorns,a large proportion of stage Ⅰ-Ⅱ disease and low in-ternational prognostic factor(IP1) score. The 5-year overall survival(OS) rate for all patients was 78.9%. The corresponding OS rate was 82.5% for gastrointestinal origin, 37.0% for CNS and testis origin and 74.6% for other organ origin, respectively. On univariate analysis, performance status, IPI score and more than one extranedal site involvement were the prognostic predictors for 5-year OS. Conclusions Being a heterogeneous group of lymphomas, extranedal DLBCL has good prognosis except those derived from the CNS and testis.