CAJ | 학술논문

目的探讨慢性乙型肝炎患者血小板减少的发病机制.方法对76例慢性乙型肝炎和肝硬化血小板减少患者进行血清促血小板生成素(TPO)水平、巨核细胞(MK)计数、血小板相关免疫球蛋白G(PAIgG)、脾脏指数(SPI)、凝血酶原活动度(PTA)检查.结果多元线性逐步回归分析显示,Pt与血清TPO水平、MK计数、SPI、PTA相关(r值分别为0.450、0.521、-0.438、0.428.P<0.05),所得数学模型:Pt=36.38+0.23TPO-0.57SPI+0.69MK,R2=0.57,F=18.78,P<0.01 .结论血清TPO水平下降、骨髓巨核细胞系统抑制及脾功能亢进在慢性乙型肝炎患者血小板减少的发病机制中起重要作用.
목적 탐토만성을형간염환자혈소판감소적발병궤제.방법 대76례만성을형간염화간경화혈소판감소환자진행혈청촉혈소판생성소(TPO)수평、거핵세포(MK)계수、혈소판상관면역구단백G(PAIgG)、비장지수(SPI)、응혈매원활동도(PTA)검사.결과 다원선성축보회귀분석현시,Pt여혈청TPO수평、MK계수、SPI、PTA상관(r치분별위0.450、0.521、-0.438、0.428.P<0.05),소득수학모형:Pt=36.38+0.23TPO-0.57SPI+0.69MK,R2=0.57,F=18.78,P<0.01 .결론 혈청TPO수평하강、골수거핵세포계통억제급비공능항진재만성을형간염환자혈소판감소적발병궤제중기중요작용.
Objective To explore the pathogenesis of thrombocytopenia in chronic type B hepatitis. Methods The serum thrombopoietin (TPO) levels, bone marrow megakaryocyte (MK) count, platelet-associated immunoglobulin G (PAIgG), splenic index (SPI), prothrombin activity (PTA) were measured in 76 chronic type B hepatitis patients with thrombocytopenia. Results The regression analysis revealed that the platelet count was correlated with parameters including the serum TPO levels, bone MK count, SPI and PTA (r was 0.450, 0.521, -0.438, 0.428 respectively, P<0.05). The regression equation was Pt=36.38+0.23 TPO-0.57 SPI+0.69 MK, R<'2>=0.57, F=18.78, P<0.01. Conclusion It suggests that decline of thrombopoiedn, myelosuppression and hypersplenism may contribute to thrombocytopenia in chronic type B hepatitis patients.