CAJ | 학술논문

背景神经病理性疼痛( neuropathic pain，NPP)是慢性疼痛中的研究热点，其产生机制复杂，治疗方法虽多，但尚未有适用于各种类型NPP的疗法。目的综述美西律在治疗NPP中的研究现状。内容美西律可阻断异常钠通道电流，缩短通道开放的持续时间，降低神经轴突的兴奋性，动物实验与临床研究表明其对缓解外周神经病变后NPP效果确切，副作用小，安全性大。趋向美西律治疗NPP具有一定疗效，今后需进一步深入研究该药在不同亚型钠通道中的阻滞作用，为临床治疗不同类型NPP提供新思路。
배경신경병이성동통( neuropathic pain，NPP)시만성동통중적연구열점，기산생궤제복잡，치료방법수다，단상미유괄용우각충류형NPP적요법。 목적종술미서률재치료NPP중적연구현상。내용미서률가조단이상납통도전류，축단통도개방적지속시간，강저신경축돌적흥강성，동물실험여림상연구표명기대완해외주신경병변후NPP효과학절，부작용소，안전성대。추향미서률치료NPP구유일정료효，금후수진일보심입연구해약재불동아형납통도중적조체작용，위림상치료불동류형NPP제공신사로。
Background Neuropathic pain is an intractable chronic pain. Due to it's complicated generation mechanism,kinds of therapy differ from one another. But there's no one effective way that suit all kinds of neuropathic pain. Objective To summarize the research status of mexiletine used in the management of neuropathic pain. Content Mexiletine, a sodium channel blocker, could effectively block abnormal sodium channel currents flow, shorten these channels' open duration, cut down the excitability of the neuraxons, thus releasing pain. Investigations in neuropathic pain treatment with mexiletine, including animal experiments and clinical researches, have gradually increased day by day. It is reported that some types of neuropathic pain,especially patients with painful peripheral neuropathy, e.g. chronic diabetic neuropathy, peripheral nerve injury, post-herpes or post-chemotherapy neuropathic pain, could be obviously relieved by mexiletine, with little side effccts and great security. Trend Mexiletine has some curative effect while treating neuropathic pain. There should be more focus on it's different blockage roles in various sodium channels, which may provide some new thoughts to treat various neuropathic pain.