国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
12期
725-728
,共4页
表皮生长因子受体%非小细胞肺癌%基因突变%转移%靶向治疗
錶皮生長因子受體%非小細胞肺癌%基因突變%轉移%靶嚮治療
표피생장인자수체%비소세포폐암%기인돌변%전이%파향치료
Epidermal growth factor receptor%Non-small cell lung cancer%Gene mutation%Metastasis%Targeted therapy
表皮生长因子受体(epidermal growth factor receptor,EGFR)是一种具有酪氨酸激酶活性的跨膜糖蛋白,可介导细胞的增殖、分化、凋亡抑制及血管生成等多种细胞过程.在多种人类恶性肿瘤中.均存在EGFR表达上调的现象,其中约70%的非小细胞肺癌(non-small cell lung cancer,NSCLC)患者表现为EGFR过表达.另外,在亚洲非吸烟的女性肺腺癌患者中,EGFR的基因突变率达40%以上,表明EGFR的异常表达与NSCLC的发生及发展有密切关系.本文主要就近年来关于EGFR过表达和基因突变与NSCLC发生及转移关系的研究作一综述.
錶皮生長因子受體(epidermal growth factor receptor,EGFR)是一種具有酪氨痠激酶活性的跨膜糖蛋白,可介導細胞的增殖、分化、凋亡抑製及血管生成等多種細胞過程.在多種人類噁性腫瘤中.均存在EGFR錶達上調的現象,其中約70%的非小細胞肺癌(non-small cell lung cancer,NSCLC)患者錶現為EGFR過錶達.另外,在亞洲非吸煙的女性肺腺癌患者中,EGFR的基因突變率達40%以上,錶明EGFR的異常錶達與NSCLC的髮生及髮展有密切關繫.本文主要就近年來關于EGFR過錶達和基因突變與NSCLC髮生及轉移關繫的研究作一綜述.
표피생장인자수체(epidermal growth factor receptor,EGFR)시일충구유락안산격매활성적과막당단백,가개도세포적증식、분화、조망억제급혈관생성등다충세포과정.재다충인류악성종류중.균존재EGFR표체상조적현상,기중약70%적비소세포폐암(non-small cell lung cancer,NSCLC)환자표현위EGFR과표체.령외,재아주비흡연적녀성폐선암환자중,EGFR적기인돌변솔체40%이상,표명EGFR적이상표체여NSCLC적발생급발전유밀절관계.본문주요취근년래관우EGFR과표체화기인돌변여NSCLC발생급전이관계적연구작일종술.
Epidermal growth factor receptor(EGFR) is a type of transmembrane glycoprotein with tyrosine kinase activity. It can induce several cell processes such as proliferation, differentiation, apoptosis inhibition, angiogenesis, and so on. EGFR is upregulated commonly in many types of human malignant tumors. EGFR overexpressed in 70% of patients with non-small cell lung cancer(NSCLC). Moreover, in female nonsmokers with lung adenocarcinoma in Asia, the rate of EGFR mutation is over 40%. Studies indicate that the abnormal expression of EGFR is related to the genesis and development of NSCLC. This article reviews correlations between EGFR overexpression and mutation and the genesis and progression of NSCLC in recent years.
