国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
14期
7-10
,共4页
谭奕洲%唐漾波%袁小珍%蔡晓莉%陈伟烈
譚奕洲%唐漾波%袁小珍%蔡曉莉%陳偉烈
담혁주%당양파%원소진%채효리%진위렬
乙型肝炎病毒%乙肝病毒外膜大蛋白%抗病毒治疗
乙型肝炎病毒%乙肝病毒外膜大蛋白%抗病毒治療
을형간염병독%을간병독외막대단백%항병독치료
Hepatitis B virus%Hepatitis B vires large surface protein%Antiviral therapy
目的 通过检测抗病毒治疗患者血清中乙肝病毒外膜大蛋白(HBV-LP)和病毒载量(HBV-DNA),探讨阿德福韦抗病毒治疗过程中HBV-LP与HBV-DNA的关系,观察HBV-LP用于评估抗病毒治疗效果的应用价值.方法 采用酶联免疫吸附试验(ELISA)方法对HBV-LP进行检测;采用荧光定量PCR方法对HBV-DNA进行检测.结果 抗病毒治疗有效组患者HBV-DNA和HBV-LP下降趋势一致;抗病毒治疗无效组患者HBV-DNA始终没有出现阴转,HBV-LP的含量维持在较高水平;抗病毒治疗效果反复组患者HBV-LP的含量维持较高水平或变化不明显,HBV-DNA则出现暂时阴转.结论 动态监测HBV-LP的含量可用于阿德福韦抗病毒治疗效果的评估.
目的 通過檢測抗病毒治療患者血清中乙肝病毒外膜大蛋白(HBV-LP)和病毒載量(HBV-DNA),探討阿德福韋抗病毒治療過程中HBV-LP與HBV-DNA的關繫,觀察HBV-LP用于評估抗病毒治療效果的應用價值.方法 採用酶聯免疫吸附試驗(ELISA)方法對HBV-LP進行檢測;採用熒光定量PCR方法對HBV-DNA進行檢測.結果 抗病毒治療有效組患者HBV-DNA和HBV-LP下降趨勢一緻;抗病毒治療無效組患者HBV-DNA始終沒有齣現陰轉,HBV-LP的含量維持在較高水平;抗病毒治療效果反複組患者HBV-LP的含量維持較高水平或變化不明顯,HBV-DNA則齣現暫時陰轉.結論 動態鑑測HBV-LP的含量可用于阿德福韋抗病毒治療效果的評估.
목적 통과검측항병독치료환자혈청중을간병독외막대단백(HBV-LP)화병독재량(HBV-DNA),탐토아덕복위항병독치료과정중HBV-LP여HBV-DNA적관계,관찰HBV-LP용우평고항병독치료효과적응용개치.방법 채용매련면역흡부시험(ELISA)방법대HBV-LP진행검측;채용형광정량PCR방법대HBV-DNA진행검측.결과 항병독치료유효조환자HBV-DNA화HBV-LP하강추세일치;항병독치료무효조환자HBV-DNA시종몰유출현음전,HBV-LP적함량유지재교고수평;항병독치료효과반복조환자HBV-LP적함량유지교고수평혹변화불명현,HBV-DNA칙출현잠시음전.결론 동태감측HBV-LP적함량가용우아덕복위항병독치료효과적평고.
Objective Detecting the serum hepatitis B virus large surface protein(HBV-LP) and hepatitis B virus DNA(HBV-DNA) load to study the correlation between HBV-LP and HBV-DNA and to evaluate the application value of the effect of HBV-LP on antiviral therapy.Methods HBV-DNA was detected by fluorescent quantitative PCR(FQ-PCR),and serum HBV-LP was detected by enzyme linked immunosorhent assay(ELISA).Results Both HBV-DNA and HSV-LP in the patients who were treated effectively with adefovir decreased,HBV-DNA in the patients who were treated ineffectively with adefovir had never turned negative and HBV-LP retained in high level and HBV-LP showed in high level or no change while HBV-DNA had turned negative temporally in the patients having relapsed symptoms to adefovir.Conclusion Measuring serum HBV-LP dynamically can be useful in evaluation of adefovir therapeutic effect.