江汉大学学报：自然科学版
江漢大學學報：自然科學版
강한대학학보：자연과학판
Journal of Jianghan University:Natural Sciences
2011年
4期
73-76
,共4页
阻塞性睡眠呼吸暂停综合征%重叠综合征%内皮素%呼吸暂停低通气指数
阻塞性睡眠呼吸暫停綜閤徵%重疊綜閤徵%內皮素%呼吸暫停低通氣指數
조새성수면호흡잠정종합정%중첩종합정%내피소%호흡잠정저통기지수
obsteructive sleep apnea syndrome%overlap syndrome%endothelial-1%apnea hypopnea index
目的：探讨阻塞性睡眠呼吸暂停综合征（OSAS）以及OSAS合并慢性阻塞性肺疾病（以下称重叠综合征）患者的血浆内皮素（ET-1）的变化及其与睡眠呼吸紊乱的关系.方法：平行开放的方法选取患者80例,其中单纯OSAS患者40例（A组）,重叠综合征患者40例（B组）,以及同期健康体检者为对照组30例（C组）,观察记录3组ET-1、呼吸暂停低通气指数（AHI）、夜间睡眠最低血氧饱和度（LSaO2）的变化.结果：（1）治疗前A、B两组ET-1、AHI均高于正常对照组（C组）,P〈0.05,其中B组最高;A、B组LSaO2低于正常对照组,B组最低;（2）治疗前、后相比,A、B两组ET-1、AHI、LSaO2差异均有统计学意义,P〈0.05,而且治疗后A、B两组相比差异有统计学意义,P〈0.05;其中B组ET-1、AHI明显降低,LSaO2明显升高;（3）治疗前、后A、B组患者ET-1与AHI呈正相关,与平均血氧饱和度呈负相关.结论：重叠综合征患者因血浆内皮素增加、气道阻力增高而加重睡眠呼吸紊乱和夜间低氧血症.内皮素可作为重叠综合征患者判断病情的较好临床指标,在呼吸科领域具有广泛的应用前景,值得临床推广.
目的：探討阻塞性睡眠呼吸暫停綜閤徵（OSAS）以及OSAS閤併慢性阻塞性肺疾病（以下稱重疊綜閤徵）患者的血漿內皮素（ET-1）的變化及其與睡眠呼吸紊亂的關繫.方法：平行開放的方法選取患者80例,其中單純OSAS患者40例（A組）,重疊綜閤徵患者40例（B組）,以及同期健康體檢者為對照組30例（C組）,觀察記錄3組ET-1、呼吸暫停低通氣指數（AHI）、夜間睡眠最低血氧飽和度（LSaO2）的變化.結果：（1）治療前A、B兩組ET-1、AHI均高于正常對照組（C組）,P〈0.05,其中B組最高;A、B組LSaO2低于正常對照組,B組最低;（2）治療前、後相比,A、B兩組ET-1、AHI、LSaO2差異均有統計學意義,P〈0.05,而且治療後A、B兩組相比差異有統計學意義,P〈0.05;其中B組ET-1、AHI明顯降低,LSaO2明顯升高;（3）治療前、後A、B組患者ET-1與AHI呈正相關,與平均血氧飽和度呈負相關.結論：重疊綜閤徵患者因血漿內皮素增加、氣道阻力增高而加重睡眠呼吸紊亂和夜間低氧血癥.內皮素可作為重疊綜閤徵患者判斷病情的較好臨床指標,在呼吸科領域具有廣汎的應用前景,值得臨床推廣.
목적：탐토조새성수면호흡잠정종합정（OSAS）이급OSAS합병만성조새성폐질병（이하칭중첩종합정）환자적혈장내피소（ET-1）적변화급기여수면호흡문란적관계.방법：평행개방적방법선취환자80례,기중단순OSAS환자40례（A조）,중첩종합정환자40례（B조）,이급동기건강체검자위대조조30례（C조）,관찰기록3조ET-1、호흡잠정저통기지수（AHI）、야간수면최저혈양포화도（LSaO2）적변화.결과：（1）치료전A、B량조ET-1、AHI균고우정상대조조（C조）,P〈0.05,기중B조최고;A、B조LSaO2저우정상대조조,B조최저;（2）치료전、후상비,A、B량조ET-1、AHI、LSaO2차이균유통계학의의,P〈0.05,이차치료후A、B량조상비차이유통계학의의,P〈0.05;기중B조ET-1、AHI명현강저,LSaO2명현승고;（3）치료전、후A、B조환자ET-1여AHI정정상관,여평균혈양포화도정부상관.결론：중첩종합정환자인혈장내피소증가、기도조력증고이가중수면호흡문란화야간저양혈증.내피소가작위중첩종합정환자판단병정적교호림상지표,재호흡과영역구유엄범적응용전경,치득림상추엄.
Objective：To study endothelial-1（ET-1） in patients with obstructive sleep apnea syndrome（OSAS） and OSAS combining with chronic obstructive pulmonary disease（overlap syndrome）,and to investigate the relation between ET-1 change and sleep-disordered breathing.Methods：80 subjects were divided into two groups： the group with OSAS（group A,40 patients）,the group with overlap syndrome（group B,40 patients）,the control group（group C,30 patients）.The changes of ET-1,apnea hypopnea index（AHI） and the lowest oxygen saturation（LSaO2） at night were compared in three groups.Results： Before the treatment,ET-1 and AHI in group A and B were signifycantly higher than those in control group（group C） P 0.05,and they were highest in group B.LSaO2 in group A and B were lower than those in control group,and they were lowest in group B.Before and after the treatment,there were signifycant differences for ET-1,AHI and LSaO2 in group A and B（P 0.05）.Futhermore,after the treatment,there was a sig-nifycant difference between group A and B.In group B,ET-1,AHI decreased,and LSaO2 in-creased obviously.ET-1 was related to AHI,and positively related to LSaO2 in group A and B.Conclusions：The increases of ET-1 and airway resistance aggravate sleep-disordered breathing and nocturnal hypoxemia for overlap syndrome patients.ET-1 is a good clinical index to judge the disease.It has a wide application prospect and deserves the clinical expansion.
