CAJ | 학술논문

目的探讨癌基因c-erbB-2和肿瘤转移抑制基因nm23H1的产物在胆囊癌组织中的表达与其生物学意义。方法采用免疫组织化学方法检测胆囊癌标本中c-erbB-2和nm23H1蛋白的表达，分析其与临床病理间关系。结果 c-erbB-2和nm23H1蛋白的阳性表达率分别为43.75%(28/64)和54.69%(35/64)。Ⅳ期胆囊癌中c-erbB-2蛋白阳性率(80%)明显高于其他期胆囊癌(P＜0.01)，c-erbB-2阳性组平均生存期差于阴性组(P＜0.05)。而nm23H1蛋白的表达与肿瘤的分化、分期和预后无关。结论在胆囊癌中，c-erbB-2和nm23H1参与肿瘤发生发展过程，c-erbB-2的表达与肿瘤的转移和预后有着密切关系。
목적 탐토암기인c-erbB-2화종류전이억제기인nm23H1적산물재담낭암조직중적표체여기생물학의의。방법 채용면역조직화학방법검측담낭암표본중c-erbB-2화nm23H1단백적표체，분석기여림상병리간관계。결과 c-erbB-2화nm23H1단백적양성표체솔분별위43.75%(28/64)화54.69%(35/64)。Ⅳ기담낭암중c-erbB-2단백양성솔(80%)명현고우기타기담낭암(P＜0.01)，c-erbB-2양성조평균생존기차우음성조(P＜0.05)。이nm23H1단백적표체여종류적분화、분기화예후무관。결론 재담낭암중，c-erbB-2화nm23H1삼여종류발생발전과정，c-erbB-2적표체여종류적전이화예후유착밀절관계。
Objective To detect the expression of oncoprotein c-erbB-2 andnm23H1 in gallbladder carcinoma and explore its biological significance. Methods The expression of c-erbB-2 and nm23H1 in gallbladder carcinoma was detected with immunohistochemistry. Meanwhile, the relationship between the expression and clinical pathology of the tumor was analyzed. Results The positive rates of the expression of oncoprotein c-erbB-2 and nm23H1 were 43.75% and 54.69%, respectively. The positivity of c-erbB-2 protein was significantly higher in gallbladder carcinoma at stage Ⅱ than in that at other stages (P<0.01). The survival time of c-erbB-2-positive group was markedly lower than that of the negative one (P<0.05). However, the expression of nm23H1 was not related to the tumor differentiation, staging and prognosis. Conclusions The protooncogene c-erbB-2 and anti-metastatic gene nm23H1 participate in the oncogenesis and development of gallbladder carcinoma and the expression of c-erbB-2 is related to the metastasis and prognosis of the tumor.