医学分子生物学杂志
醫學分子生物學雜誌
의학분자생물학잡지
FOREIGN MEDICAL SCIENCES
2009年
4期
361-364
,共4页
β-arrestin%G蛋白偶联受体%信号转导
β-arrestin%G蛋白偶聯受體%信號轉導
β-arrestin%G단백우련수체%신호전도
β-arrestins%G-protein-coupled receptors%signal transduction
β-arrestin是一类重要的信号调控蛋白和支架蛋白(scaffold).在G蛋白偶联受体(G-protein-coupled receptor,GPCR)信号转导中,β-arrestin不但可以作为GPCR信号的负性调控分子,还能作为支架蛋白促进GPCR对其他信号通路的激活,如有丝分裂原激活蛋白激酶(mitogen-activated protein kinase,MAPK)途径.另外β-arrestin还能与转录因子调节蛋白,如IKB和Mdm2相互作用间接调节NF-κB和P53介导的转录.
β-arrestin是一類重要的信號調控蛋白和支架蛋白(scaffold).在G蛋白偶聯受體(G-protein-coupled receptor,GPCR)信號轉導中,β-arrestin不但可以作為GPCR信號的負性調控分子,還能作為支架蛋白促進GPCR對其他信號通路的激活,如有絲分裂原激活蛋白激酶(mitogen-activated protein kinase,MAPK)途徑.另外β-arrestin還能與轉錄因子調節蛋白,如IKB和Mdm2相互作用間接調節NF-κB和P53介導的轉錄.
β-arrestin시일류중요적신호조공단백화지가단백(scaffold).재G단백우련수체(G-protein-coupled receptor,GPCR)신호전도중,β-arrestin불단가이작위GPCR신호적부성조공분자,환능작위지가단백촉진GPCR대기타신호통로적격활,여유사분렬원격활단백격매(mitogen-activated protein kinase,MAPK)도경.령외β-arrestin환능여전록인자조절단백,여IKB화Mdm2상호작용간접조절NF-κB화P53개도적전록.
β-arrestins are a family of important signaling adapter proteins and scaffold proteins. β-arrestins function not only as negative regulators of G-protein-coupled receptor (GPCR) signaling transduction, but also as scaffold proteins that promote other signaling pathways, such as Mitogen-activated protein kinase(MAPK) activated by GPCR. In addition, β-arrestin interacts with regulators of transcription factors, such as IκB and MDM2, and regulates indirectly transcription of NF-κB and p53.
