CAJ | 학술논문

背景:硒是人体必需的微量元素之一,是具有抗氧化功能的硒酶的活性中心,能清除体内的自由基,有效地催化有害的过氧化物还原为无害的羟基化合物,增强人体免疫力,预防和治疗心脑血管疾病和癌症.目的:比较心脑血管疾病患者血硒水平与健康者的差别,以期对心脑血管疾病的预防和治疗提供依据.设计:病例-对照分析.单位:大连铁路卫生学校,大连铁路医院,大连铁道学院应化系.对象:采集2000-03/2001-05大连铁路医院收治的心脑血管疾病患者血样319份.319例患者中男169例,女150例;高血压164例,冠状动脉粥样硬化性心脏病97例,心律失常41例,脑血管意外17例.健康组300例为同期健康体检者,男159例,女141例.方法:用新极谱法测定心脑血管疾病患者血样的血硒水平.主要观察指标:①两组受试者血硒的总体水平.②不同性别血硒水平比较.③患者组不同病种间血硒水平比较.结果:619例受试者全部进入结果分析.①患者组总体血硒水平低于健康组[(114.0±52.5),(146.5±51.0)μg/L,P＜0.001],仅为健康人的76%.②男性与女性血硒含量的概率分布均为正态分布,男女之间差异无显著性意义(P＞0.10),但血硒水平女性略高于男性.③高血压、冠状动脉粥样硬化性心脏病、心律失常患者血硒水平相当于健康组的82.7%,68.6%,66.0%,但男女之间差异不显著(P＞0.10).脑血管意外患者的血硒水平最低,为(84.4±28.9)μg/L,仅是健康人的57.6%.结论:心脑血管疾病患者血硒水平低于健康人,应适量补充有机硒和无机硒.
배경:서시인체필수적미량원소지일,시구유항양화공능적서매적활성중심,능청제체내적자유기,유효지최화유해적과양화물환원위무해적간기화합물,증강인체면역력,예방화치료심뇌혈관질병화암증.목적:비교심뇌혈관질병환자혈서수평여건강자적차별,이기대심뇌혈관질병적예방화치료제공의거.설계:병례-대조분석.단위:대련철로위생학교,대련철로의원,대련철도학원응화계.대상:채집2000-03/2001-05대련철로의원수치적심뇌혈관질병환자혈양319빈.319례환자중남169례,녀150례;고혈압164례,관상동맥죽양경화성심장병97례,심률실상41례,뇌혈관의외17례.건강조300례위동기건강체검자,남159례,녀141례.방법:용신겁보법측정심뇌혈관질병환자혈양적혈서수평.주요관찰지표:①량조수시자혈서적총체수평.②불동성별혈서수평비교.③환자조불동병충간혈서수평비교.결과:619례수시자전부진입결과분석.①환자조총체혈서수평저우건강조[(114.0±52.5),(146.5±51.0)μg/L,P＜0.001],부위건강인적76%.②남성여녀성혈서함량적개솔분포균위정태분포,남녀지간차이무현저성의의(P＞0.10),단혈서수평녀성략고우남성.③고혈압、관상동맥죽양경화성심장병、심률실상환자혈서수평상당우건강조적82.7%,68.6%,66.0%,단남녀지간차이불현저(P＞0.10).뇌혈관의외환자적혈서수평최저,위(84.4±28.9)μg/L,부시건강인적57.6%.결론:심뇌혈관질병환자혈서수평저우건강인,응괄량보충유궤서화무궤서.
BACKGROUND: Selenium is one of necessary microelement of human body. It acts as the active center of selenium-contained enzyme with antioxidant function, which can clean up internal free radical, effectively catalyze harmful perhydride deoxidizing into innocuous hydroxyl compound,reinforce immunity of human body, prevent and cure cardio-cerebrovascular diseases and cancer.OBJECTIVE: To provide evidence for preventing and treating cardiocerebrovascular diseases via comparison of blood selenium content between patients and healthy persons.DESIGN: Case-control analysis.SETTING: Dalian Railway Medical School, Dalian Railway Hospital, Department of Applied Chemistry, Dalian Railway College.PARTICIPANTS: Totally 319 blood samples (169 males, 150 females)were collected from patients with cardio-cerebrovascular diseases from Dalian Railway Hospital from March 2000 to May 2001. Among them,there were 164 with hypertension, 97 with coronary atherosclerotic heart disease (CAHD), 41 with cardiac dysrhythmia and 17 with cerebral vascular accident. 300 healthy patients (159 males and 141 females) were in the healthy group.METHODS: The blood selenium content of patients with cardio-cerebrovascular diseases was detected with neopolarography.MAIN OUTCOME MEASURES: ①Total level of blood selenium of testees of the two groups. ②Comparison of level of blood selenium between males and females. ③Comparison of level of blood selenium of patients with different diseases.RESULTS: A total of 619 testees were involved in the result analysis. ①The total level of blood selenium of the patient group was lower than that of the healthy group [(114.0±52.5), (146.5±51.0) μg/L,P ＜ 0.001],which was only 76% of that of the healthy persons. ②Content of blood selenium of males and females was normal distribution. There was insignificant difference between males and females (P ＞ 0.10), but the level of blood selenium in females was slightly higher than that of males. ③The levels of blood selenium of patients with hypertension, CAHD, cardiac dysrhythmia were 82.7%, 68.6% and 66.0% of that of healthy persons, respectively, but the difference between males and females was insignificant(P ＞ 0.10). The level of blood selenium of patients with cerebrovascular accident (CVA) was the lowest, (84.4±28.9)μg/L, which was 57.6% of healthy persons.CONCLUSION: The content of blood selenium of patients with cardiocerebrovascular diseases is lower than that of healthy persons. Organic selenium and inorganic selenium should be supplemented moderately.