天然产物研究与开发
天然產物研究與開髮
천연산물연구여개발
NATURAL PRODUCT RESEARCH AND DEVELOPMENT
2012年
7期
888-891,919
,共5页
白色念珠菌%NEI%大蒜素
白色唸珠菌%NEI%大蒜素
백색념주균%NEI%대산소
Candida albicans%NEI%allicin
本研究旨在探讨大蒜素对白色念珠菌感染小鼠神经内分泌免疫系统(NEI)的调节作用.将小鼠随机分为三组:正常对照组、模型组、大蒜素组.除正常对照组外,模型组、大蒜素组分别建立小鼠白色念珠菌感染模型.大蒜素组小鼠给予大蒜素灌胃,其余组给予等量生理盐水.连续用药14 d后,各组小鼠取血测定促肾上腺激素(ACTH)、皮质酮(CORT)、β-内啡肽(β-EP)、5-羟色胺(5-HT)的水平,测定胸腺指数及脾脏淋巴细胞增殖活性.实验结果显示,模型组小鼠NEI功能发生紊乱,与正常对照组相比,ACTH、CORT、β-EP水平均明显升高,5-HT、胸腺指数及脾脏淋巴细胞增殖活性均明显下降,差异有显著性(P＜0.05).而大蒜素组小鼠ACTH、CORT、β-EP水平较之模型组明显下降,5-HT、胸腺指数及脾脏淋巴细胞增殖活性明显升高,差异有显著性(P＜0.05).综上所述,本研究提示大蒜素对白色念珠菌感染小鼠紊乱的NEI具有明显的调节作用.
本研究旨在探討大蒜素對白色唸珠菌感染小鼠神經內分泌免疫繫統(NEI)的調節作用.將小鼠隨機分為三組:正常對照組、模型組、大蒜素組.除正常對照組外,模型組、大蒜素組分彆建立小鼠白色唸珠菌感染模型.大蒜素組小鼠給予大蒜素灌胃,其餘組給予等量生理鹽水.連續用藥14 d後,各組小鼠取血測定促腎上腺激素(ACTH)、皮質酮(CORT)、β-內啡肽(β-EP)、5-羥色胺(5-HT)的水平,測定胸腺指數及脾髒淋巴細胞增殖活性.實驗結果顯示,模型組小鼠NEI功能髮生紊亂,與正常對照組相比,ACTH、CORT、β-EP水平均明顯升高,5-HT、胸腺指數及脾髒淋巴細胞增殖活性均明顯下降,差異有顯著性(P＜0.05).而大蒜素組小鼠ACTH、CORT、β-EP水平較之模型組明顯下降,5-HT、胸腺指數及脾髒淋巴細胞增殖活性明顯升高,差異有顯著性(P＜0.05).綜上所述,本研究提示大蒜素對白色唸珠菌感染小鼠紊亂的NEI具有明顯的調節作用.
본연구지재탐토대산소대백색념주균감염소서신경내분비면역계통(NEI)적조절작용.장소서수궤분위삼조:정상대조조、모형조、대산소조.제정상대조조외,모형조、대산소조분별건립소서백색념주균감염모형.대산소조소서급여대산소관위,기여조급여등량생리염수.련속용약14 d후,각조소서취혈측정촉신상선격소(ACTH)、피질동(CORT)、β-내배태(β-EP)、5-간색알(5-HT)적수평,측정흉선지수급비장림파세포증식활성.실험결과현시,모형조소서NEI공능발생문란,여정상대조조상비,ACTH、CORT、β-EP수평균명현승고,5-HT、흉선지수급비장림파세포증식활성균명현하강,차이유현저성(P＜0.05).이대산소조소서ACTH、CORT、β-EP수평교지모형조명현하강,5-HT、흉선지수급비장림파세포증식활성명현승고,차이유현저성(P＜0.05).종상소술,본연구제시대산소대백색념주균감염소서문란적NEI구유명현적조절작용.
The objective of this study was to investigate the regulation of allicin on NEI of mice which were normal control group,model group and allicin group.Model group and allicin group were established the model of Candida albicans infection in mice.The mice of allicin group were given allicin orally,the others were given normal saline as a control.Continuous medication for 14 days,mice in each group were measured the levels of adrenocorticotropic hormone (ACTH),corticosterone (CORT),β-endorphin (β-EP) and 5-hydroxytryptamine (5-HT) by blood,and the thymus index and spleen lymphocyte proliferation activity.The results showed that the NEI function of mice in model group disordered which compared with the control group,the levels of ACTH,CORT,β-EP were significantly higher,while 5-HT,thymus index and spleen lymphocyte proliferation activity decreased significantly,of which the differences were significant(P ＜0.05).The levels of ACTH,CORT,β-EP in allicin group were significantly lower than the model group,5-HT,thymus index and spleen lymphocyte proliferation activity was significantly higher,of which the differences were significant ( P ＜ 0.05).Above all,allicin has a significant regulatory role on disordered NEI of mice which were infected by C.
