CAJ | 학술논문

白细胞介素-1(interleukin-1,IL-1)系统分子广泛分布于中枢神经系统.中枢IL-1具有极其丰富的生物学功能,作为经典炎性细胞因子,在多种生理、病理生理过程中起重要作用.近几年来,中枢IL-1的应激介质作用备受关注.本文综述了中枢IL-1在应激反应中作用的最新进展,包括应激对中枢IL-1系统的影响,中枢IL-1对应激反应的启动和介导作用;参与中枢IL-1-应激介导作用的神经环路和细胞信号转导通路,以及中枢IL-1对应激时脑高级功能和行为反应的影响.
백세포개소-1(interleukin-1,IL-1)계통분자엄범분포우중추신경계통.중추IL-1구유겁기봉부적생물학공능,작위경전염성세포인자,재다충생리、병리생리과정중기중요작용.근궤년래,중추IL-1적응격개질작용비수관주.본문종술료중추IL-1재응격반응중작용적최신진전,포괄응격대중추IL-1계통적영향,중추IL-1대응격반응적계동화개도작용;삼여중추IL-1-응격개도작용적신경배로화세포신호전도통로,이급중추IL-1대응격시뇌고급공능화행위반응적영향.
The molecules of interleukin-1 (IL-1) system are widely distributed in central nervous system. As a classical pro-inflammatory facto r, central IL-1 has diverse biological functions and plays a pivotal role in a number of important physiological and pathophysiological processes. During the past few years, particular attentions have been directed to the stress mediator actions of central IL-l. This paper reviews some recent findings in the studies of central IL- 1 functions in stress responses, including the effects of stress on central IL-1, the roles of IL-1 in the initiation of stress responses, the neural circuitries and intracellular signal transduction pathways involved in the central IL-1 mediated stress responses, as well as the actions of central IL-1 on brain high function and behavior under stressful conditions.