中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2008年
4期
200-203
,共4页
钱秋谨%王玉凤%杨莉%刘豫鑫
錢鞦謹%王玉鳳%楊莉%劉豫鑫
전추근%왕옥봉%양리%류예흠
注意力缺陷障碍伴多动%基因%认知%多态性,单核苷酸%多巴胺
註意力缺陷障礙伴多動%基因%認知%多態性,單覈苷痠%多巴胺
주의력결함장애반다동%기인%인지%다태성,단핵감산%다파알
Attention deficit disorder with hyperactivity%Genes%Cognition%Polymorphism,single nucleotide%Dopamine
目的 探讨儿茶酚氧位甲基转移酶(COMT)基因Va1108/158Met(rs4680)多态性对注意缺陷多动障碍(ADHD)患儿认知功能的影响.方法 对203例中国汉族ADHD患儿进行韦氏记忆测查、Stroop测验及数字划消测查,评定记忆力、反应抑制能力和注意力,并检测COMT基因Va1158Met多态性.按照基因型将样本分为高活性基因型组(92例,ValVal)和中低活性基因型组(111例,ValMet和MetMet),比较两组间各项测查结果的异同.结果 高活性基因型组图片分测验[(11.7±3.1)分]和Stroop测验C部分错误数(0个)的成绩好于中低活性基因型组[分别为(10.8±2.9)分和1个;P＜0.05～0.01].两组其他方面的差异均无统计学意义.结论 COMT基因Val158Met多态性与ADHD患儿的认知功能中的记忆力、反应抑制能力和注意力相关.
目的 探討兒茶酚氧位甲基轉移酶(COMT)基因Va1108/158Met(rs4680)多態性對註意缺陷多動障礙(ADHD)患兒認知功能的影響.方法 對203例中國漢族ADHD患兒進行韋氏記憶測查、Stroop測驗及數字劃消測查,評定記憶力、反應抑製能力和註意力,併檢測COMT基因Va1158Met多態性.按照基因型將樣本分為高活性基因型組(92例,ValVal)和中低活性基因型組(111例,ValMet和MetMet),比較兩組間各項測查結果的異同.結果 高活性基因型組圖片分測驗[(11.7±3.1)分]和Stroop測驗C部分錯誤數(0箇)的成績好于中低活性基因型組[分彆為(10.8±2.9)分和1箇;P＜0.05～0.01].兩組其他方麵的差異均無統計學意義.結論 COMT基因Val158Met多態性與ADHD患兒的認知功能中的記憶力、反應抑製能力和註意力相關.
목적 탐토인다분양위갑기전이매(COMT)기인Va1108/158Met(rs4680)다태성대주의결함다동장애(ADHD)환인인지공능적영향.방법 대203례중국한족ADHD환인진행위씨기억측사、Stroop측험급수자화소측사,평정기억력、반응억제능력화주의력,병검측COMT기인Va1158Met다태성.안조기인형장양본분위고활성기인형조(92례,ValVal)화중저활성기인형조(111례,ValMet화MetMet),비교량조간각항측사결과적이동.결과 고활성기인형조도편분측험[(11.7±3.1)분]화Stroop측험C부분착오수(0개)적성적호우중저활성기인형조[분별위(10.8±2.9)분화1개;P＜0.05～0.01].량조기타방면적차이균무통계학의의.결론 COMT기인Val158Met다태성여ADHD환인적인지공능중적기억력、반응억제능력화주의력상관.
Objective To investigate the association of catechol-O-methyltransferase (COMT) gene Vl108/158Met SNP (rs4680)with cognitive function in children with attention deficit hyperactivity disorder(ADHD) in China. Methods A total of 203 DSM-1V ADHD children of Chinese Hart descent were included, both the data of neuropsychological tests ( Wechsler Memory Scale, Stroop test and cancellationtest) and COMT Val108/158Met genotyping results were obtained. The two-sample t test and Mann-Whitney test were used to compare the average scores between two groups defined by COMT Val158Met genotypes,high-enzymatic activity ( ValVal, n = 92) and mid-low enzymatic activity ( ValMet and MetMet, n = 111 ).Results The children with high-enzymatic activity (ValVal) performed significantly better on some aspects of Wechsler Memory Scale and Stroop test ( picture recall, and part C error number in Stroop test) than those with mid-low enzymatic activity (P ＜0.05-0.01 ). No statistically significant differences were found between two groups and index in other tests. Conclusion The results suggest that COMT gene Val108/158Met polymorphism may be related to the cognitive functions as memory, response in hibition and attention in ADHD children in China.
