中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
2期
191-192
,共2页
胰腺炎%参芎注射液%七叶皂苷钠%临床试验
胰腺炎%參芎註射液%七葉皂苷鈉%臨床試驗
이선염%삼궁주사액%칠협조감납%림상시험
Pancreatitis%Shenxiong injection%Aescinate%Clinical trials
目的 了解参芎注射液及七叶皂苷钠对急性胰腺炎(AP)患者血浆内皮素浓度的影响及其改善微循环的作用.方法 将87例AP患者完全随机分为对照组20例、单用组33例、联合组34例.3组均采用常规治疗,单用组加用参芎注射液治疗,联合组加用参芎注射液和七叶皂苷钠治疗,观察各组腹痛、腹部压痛、血尿淀粉酶及内皮素等变化情况.结果 单用组和联合组腹部压痛消失、肠道功能恢复、血尿淀粉酶和影像学恢复时间及平均治疗时间均短于对照组(P＜0.05);联合组肠道功能恢复、血尿淀粉酶和影像学恢复时间及平均治疗时间均短于单用组(P＜0.05).单用组和联合组患者治疗后血浆内皮素浓度[(64.79±7.58)ng/L、(47.80±7.14)ng/L]明显低于治疗前[(104.77±6.57)ng/L、(103.41±7.53)ng/L](P＜0.05).结论 在常规治疗的基础上联合应用参芎注射液、七叶皂苷钠治疗AP具有良好的临床疗效,值得临床推广.
目的 瞭解參芎註射液及七葉皂苷鈉對急性胰腺炎(AP)患者血漿內皮素濃度的影響及其改善微循環的作用.方法 將87例AP患者完全隨機分為對照組20例、單用組33例、聯閤組34例.3組均採用常規治療,單用組加用參芎註射液治療,聯閤組加用參芎註射液和七葉皂苷鈉治療,觀察各組腹痛、腹部壓痛、血尿澱粉酶及內皮素等變化情況.結果 單用組和聯閤組腹部壓痛消失、腸道功能恢複、血尿澱粉酶和影像學恢複時間及平均治療時間均短于對照組(P＜0.05);聯閤組腸道功能恢複、血尿澱粉酶和影像學恢複時間及平均治療時間均短于單用組(P＜0.05).單用組和聯閤組患者治療後血漿內皮素濃度[(64.79±7.58)ng/L、(47.80±7.14)ng/L]明顯低于治療前[(104.77±6.57)ng/L、(103.41±7.53)ng/L](P＜0.05).結論 在常規治療的基礎上聯閤應用參芎註射液、七葉皂苷鈉治療AP具有良好的臨床療效,值得臨床推廣.
목적 료해삼궁주사액급칠협조감납대급성이선염(AP)환자혈장내피소농도적영향급기개선미순배적작용.방법 장87례AP환자완전수궤분위대조조20례、단용조33례、연합조34례.3조균채용상규치료,단용조가용삼궁주사액치료,연합조가용삼궁주사액화칠협조감납치료,관찰각조복통、복부압통、혈뇨정분매급내피소등변화정황.결과 단용조화연합조복부압통소실、장도공능회복、혈뇨정분매화영상학회복시간급평균치료시간균단우대조조(P＜0.05);연합조장도공능회복、혈뇨정분매화영상학회복시간급평균치료시간균단우단용조(P＜0.05).단용조화연합조환자치료후혈장내피소농도[(64.79±7.58)ng/L、(47.80±7.14)ng/L]명현저우치료전[(104.77±6.57)ng/L、(103.41±7.53)ng/L](P＜0.05).결론 재상규치료적기출상연합응용삼궁주사액、칠협조감납치료AP구유량호적림상료효,치득림상추엄.
Objective To study clinical effects of Shenxiong injection and aescinate in the treatment of acute pancreatitis,and to understand the effect of Shenxiong injection and aescinate on the concentration of plasma endothelin(ET) in patients with acute pancreatitis(AP). Methods Eighty-seven cases of AP patients were randomly divided into group A(20 cases) and the control group B(33) and group C(34). A group had conventional therapy,B group had the conventional treatment plus Shenxiong injection and C group had conventional treatment plus Shenxiong injection and aescinate. The plasma concentrations of ET were mensurated with radiation immunoassay(RIA). Results The pain disappearance time had no significant difference(P ＞0.05) among the three groups.The time of abdominal tenderness disappearance,intestinal function recovery,hematuria amylase recovery,imaging recovery and average hospitalization were shorter in B group and in C group than those in control group(A group)(P ＜0.05). The plasma ET concentrations after treatment were significantly lower than that before treatment in group B and C(P＜0.05). Conclusions The therapy based on the conventional treatment combined with Shenxiong injection and aescinate has good curative effect in patients with acute pancreatitis.
