CAJ | 학술논문

从2-取代-4.5-二氯哒嗪酮(1)出发，使2-取代-4-氯-5-羟基哒嗪酮(2)与溴乙基氨基甲酸酯反应合成含哒嗪酮的氨基甲酸酯类化合物(5a，5b).将化合物1与乙醇胺反应制得2-取代-4-氯-5-(2-氨基乙氧)哒嗪酮(3)，化合物3与氯甲酸酯反应得到5a～51.化合物3催化加氢生成2-取代-5-(2-氨基乙氧)哒嗪酮(4).化合物4与氯甲酸酯在-10～-5℃反应得到化合物(6a～6d)，在0～15 C反应得到相应N，N-二甲酸酯化合物(7a，7b).探讨了中间体3与4的反应活性.生物活性测试结果表明其中一些化合物具有较好的杀菌活性.
종2-취대-4.5-이록달진동(1)출발，사2-취대-4-록-5-간기달진동(2)여추을기안기갑산지반응합성함달진동적안기갑산지류화합물(5a，5b).장화합물1여을순알반응제득2-취대-4-록-5-(2-안기을양)달진동(3)，화합물3여록갑산지반응득도5a～51.화합물3최화가경생성2-취대-5-(2-안기을양)달진동(4).화합물4여록갑산지재-10～-5℃반응득도화합물(6a～6d)，재0～15 C반응득도상응N，N-이갑산지화합물(7a，7b).탐토료중간체3여4적반응활성.생물활성측시결과표명기중일사화합물구유교호적살균활성.
Pyridazinone-carbamate derivatives 5a～51 were synthesized starting from 2-substituted4,5-dichloro pyridazinones 1 via two routes. One is that 2-substituted-4-chloro-5-hydroxyl pyridazinones 2 reacted with β-bromoethyl carbamates to afford compounds 5a and 5b. The other is that 2-substituted-4-chloro-5-(2-amino ethyloxyl)pyridazinones 3 obtained from the reaction of 1 with amino ethanol, reacted with chloroformate to give 5a～51. Furthermore, the catalytic hydrogenation of 3 gave 2-substituted-5-(2-amino ethyloxyl)pyridazinones 4, which reacted with chloromates to produce compounds 6a～6d at temperatures between -10～-5 C, and to N,N-dicarbamates 7a and 7b at 0～15 C. The reactivity of intermidiates 3 and 4 was also discussed. The preliminary bioassay indicated that almost all of the compounds showed fungicidal activities.