CAJ | 학술논문

目的观察阿霉素乙基纤维素(ADM-EC)微球经大鼠肝动脉化疗栓塞对肿瘤生长及自然生存期的影响。方法 ADM-EC经肝动脉插管注射治疗Wistar大鼠W256移植性肝癌，实验共分5组：Ⅰ组(对照组)、Ⅱ组(注射生理盐水组)、Ⅲ组(注射盐酸阿霉素组)、Ⅳ组〔注射空白乙基纤维素(EC)微球组〕及Ⅴ组(注射ADM-EC微球组)。结果 ADM-EC组的肿瘤生长抑制程度、坏死程度及荷瘤自然生存期显著优于其它各组。结论经肝动脉注射ADM-EC微球可抑制肿瘤生长，促进肿瘤坏死，延长生存期，从而大大提高肿瘤化疗的疗效。
목적관찰아매소을기섬유소(ADM-EC)미구경대서간동맥화료전새대종류생장급자연생존기적영향。방법 ADM-EC경간동맥삽관주사치료Wistar대서W256이식성간암，실험공분5조：Ⅰ조(대조조)、Ⅱ조(주사생리염수조)、Ⅲ조(주사염산아매소조)、Ⅳ조〔주사공백을기섬유소(EC)미구조〕급Ⅴ조(주사ADM-EC미구조)。결과 ADM-EC조적종류생장억제정도、배사정도급하류자연생존기현저우우기타각조。결론경간동맥주사ADM-EC미구가억제종류생장，촉진종류배사，연장생존기，종이대대제고종류화료적료효。
Objective　 To investigate the growth of tumors and the natural life length of the rats after the adriamycin-ethylcellulose microspheres(ADM-EC mc) were injected in the rats bearing transplantable liver cancer through their hepatic arteries. Methods 　ADM-EC mc were infused into the proper hepatic arteries of the Wistar rats (W256). All of the rats were divided randomly into five groups, group 1: control, group 2: normal saline, group 3: conventional ADM, group 4: placebo ethylcellulose microspheres, and group 5: ADM-EC mc. Results　 As compared with other four groups, the ADM-EC mc (group 5) showed the best inhibition of the growth of tumors and the longest mean life length of the rats. Conclusion　Hepatic arterial infusion of ADM-EC mc can inhibit the growth of the tumor, aggravate the necrosis, and improve the effects of the chemotherapy of liver cancer.