CAJ | 학술논문

目的：探讨古尼拟青霉水-醇提取物对大鼠高脂血症的影响。方法：80只Wistar大鼠随机分成预防和治疗两组，预防组和治疗组再分成5个和4个小组。采用异丙醇抽提、三氯化铁-冰醋酸-硫酸显色法(修改LRC法)检测血清总胆固醇(TCh)，用异丙醇抽提、乙酰丙酮显色法检测血清甘油三酯(TG)，用磷钨酸镁法检测血清高密度脂蛋白-胆固醇(HDL-C)，用等式LDL-C=TCh-(HDL-C)-0.2TG计算血清低密度脂蛋白-胆固醇(LDL-C)。结果：预防组和治疗组TCh、TG、LDL-C、LDL-C/TCh均降低，HDL-C、HDL-C/TCh均增高。结论：古尼拟青霉水-醇提取物能预防和治疗大鼠高脂血症，并可预防动脉粥样硬化症的形成。
목적：탐토고니의청매수-순제취물대대서고지혈증적영향。방법：80지Wistar대서수궤분성예방화치료량조，예방조화치료조재분성5개화4개소조。채용이병순추제、삼록화철-빙작산-류산현색법(수개LRC법)검측혈청총담고순(TCh)，용이병순추제、을선병동현색법검측혈청감유삼지(TG)，용린오산미법검측혈청고밀도지단백-담고순(HDL-C)，용등식LDL-C=TCh-(HDL-C)-0.2TG계산혈청저밀도지단백-담고순(LDL-C)。결과：예방조화치료조TCh、TG、LDL-C、LDL-C/TCh균강저，HDL-C、HDL-C/TCh균증고。결론：고니의청매수-순제취물능예방화치료대서고지혈증，병가예방동맥죽양경화증적형성。
Objective: To explore the effects of Paecilomyces Gunnii extracts of water-alcohol on hyperlipemia in rats. Methods: Eighty Wistar rats were divided into preventive and therapeutic groups and then redivided into 5 and 4 subgroups, respectively. Serum total cholesterol (TCh) was determined by isopropanol withdrawing and ferric-glacial acetic acid -sulfuric acid developing method(LRC method corrected), serum triglyecride (TG) by isopropanol withdrawing and acetylacetone developing method,serum high density lipoprotein-cholesterol (HDL-C) by magnesium phosphotungstate mehod, respectively. Serum low density lipoprotein-cholesterol (LDL-C) was calculated by the equation: LDL-C=TCh-(HDL-C)-0.2 TG. Results: TCh、 TG、 LDL-C and LDL-C/TCh in rats of both preventive and therapeutic group were decreased while HDL and HDL-C/TCh in them were increased. Conclusion: Paecilomyces Gunnii extracts of water-alcohol can prevent and treat hyperlipemia in rats. It is possible for them to prevent formation of atherosclerosis.