广东医学
廣東醫學
엄동의학
GUNAGDONG MEDICAL JOURNAL
2001年
1期
22-23
,共2页
吴健%孙颖%金忆%谭新洪%郑勤伟
吳健%孫穎%金憶%譚新洪%鄭勤偉
오건%손영%금억%담신홍%정근위
肺%缺血%再灌注损伤%内皮缩血管肽%一氧化氮
肺%缺血%再灌註損傷%內皮縮血管肽%一氧化氮
폐%결혈%재관주손상%내피축혈관태%일양화담
目的 探讨肺缺血再灌注(I-R)中内皮细胞功能的变化。方法 制备兔肺缺血再灌注模型,设立伪手术对照,测定缺血期和缺血后再灌注不同时相的血浆一氧化氮(NO)和内皮素(ET-1)的水平,分析NO,ET-1与血气指标、肺水肿等指标的关系。结果 缺血再灌注组与对照组比较,血浆NO,ET-1水平显著增高,NO/ET-1值明显降低,动脉氧分压明显降低,肺湿/干重比增加。ET-1与动脉氧分压呈负相关,与肺湿/干重比呈正相关。结论 肺I-R状态下,内皮细胞功能紊乱与低氧和肺水肿有关联。
目的 探討肺缺血再灌註(I-R)中內皮細胞功能的變化。方法 製備兔肺缺血再灌註模型,設立偽手術對照,測定缺血期和缺血後再灌註不同時相的血漿一氧化氮(NO)和內皮素(ET-1)的水平,分析NO,ET-1與血氣指標、肺水腫等指標的關繫。結果 缺血再灌註組與對照組比較,血漿NO,ET-1水平顯著增高,NO/ET-1值明顯降低,動脈氧分壓明顯降低,肺濕/榦重比增加。ET-1與動脈氧分壓呈負相關,與肺濕/榦重比呈正相關。結論 肺I-R狀態下,內皮細胞功能紊亂與低氧和肺水腫有關聯。
목적 탐토폐결혈재관주(I-R)중내피세포공능적변화。방법 제비토폐결혈재관주모형,설립위수술대조,측정결혈기화결혈후재관주불동시상적혈장일양화담(NO)화내피소(ET-1)적수평,분석NO,ET-1여혈기지표、폐수종등지표적관계。결과 결혈재관주조여대조조비교,혈장NO,ET-1수평현저증고,NO/ET-1치명현강저,동맥양분압명현강저,폐습/간중비증가。ET-1여동맥양분압정부상관,여폐습/간중비정정상관。결론 폐I-R상태하,내피세포공능문란여저양화폐수종유관련。
Objective To study the function of circulating endothelium in lung with ischemia reperfusion.Methods The rabbit's pulmonary models of ischemia reperfusion (I-R) injury were established. 14 rabbits were randomized into sham treated control and I-R (n=7) groups. Blood specimens were collected in different testing periods in control and I-R groups to detect the concentrations of plasma NO and ET-1 and arterial oxygen tension. Wet and dry weight were calculated. Results Compared with those in sham treated control groups, the plasma concentrations of NO and ET-1 in I-R animals were increased significantly. The relationship analysis showed that the concentrations of ET-1 had significantly negative relation with that of PaO2 and positive relation with the value of the wet: dry weight ratios. Conclusion In the I-R group, the function of circulation endothelium had been damaged which may be related to hypoxia and pulmonary edema.