CAJ | 학술논문

目的探讨同型半胱氨酸(Homocysteine,Hcy)与2型糖尿病病人合并早期糖尿病肾病的关系.方法应用高效液相色谱分析法测定67例2型糖尿病病人和47例正常人的血浆Hcy水平,并同步检测可溶性血栓调节蛋白(sTM)、叶酸和维生紊B12.结果2型糖尿病病人血浆Hcy水平明显高于对照人群(15.27±6.04μmol/L vs 12.10±1.86μmol/L;P《0.01),而合并早期糖尿病肾病的血浆Hcy水平又高于无糖尿病肾病患者(17.86±8.04μmol/L vs 13.83±4.00μmol/L;P《0.01);存在高Hcy血症的糖尿病病人,其早期糖尿病肾病发生率明显高于无高Hcy血症患者(52.0%vs 26.2%;P《0.05),且前者存在着较高水平的sTM(P《0.05).结论高Hcy血症与2型糖尿病早期肾病的发病有关,其机制可能是通过血管内皮损伤所致.
목적탐토동형반광안산(Homocysteine,Hcy)여2형당뇨병병인합병조기당뇨병신병적관계.방법응용고효액상색보분석법측정67례2형당뇨병병인화47례정상인적혈장Hcy수평,병동보검측가용성혈전조절단백(sTM)、협산화유생문B12.결과2형당뇨병병인혈장Hcy수평명현고우대조인군(15.27±6.04μmol/L vs 12.10±1.86μmol/L;P《0.01),이합병조기당뇨병신병적혈장Hcy수평우고우무당뇨병신병환자(17.86±8.04μmol/L vs 13.83±4.00μmol/L;P《0.01);존재고Hcy혈증적당뇨병병인,기조기당뇨병신병발생솔명현고우무고Hcy혈증환자(52.0%vs 26.2%;P《0.05),차전자존재착교고수평적sTM(P《0.05).결론고Hcy혈증여2형당뇨병조기신병적발병유관,기궤제가능시통과혈관내피손상소치.
Objective To investigate the relationship between Homocysteine (Hcy) and incipient diabetic nephropathy in type 2 diabetes mellitus (DM).Methods The plasma Hcy level was measured by high performance liquid chromatography with fluorescence detection in 67 patients with type 2 DM and 47 control persons,the plasma thrombomodulin(sTM),folate and vitamin B 12 were determined simultaneously.Results The plasma Hcy level was higher in type 2 DM patients than that in control subjects (15.27±6.04μmol/L vs 12.10±1.86μmol/L, P <0.01),and the plasma Hcy level was higher in incipient diabetic nephropathy patients than that in non nephropathy patients (17.86± 8.04 μmol/L vs 13.83±4.00μmol/L, P <0.01).Diabetic patients with hyperhomocysteinmia had a higher diabetic nephropathy incidence rate (52.0% vs 26.2% P <0.05) compared with noe hyperhomocysteinmia patients,and the former had higher sTM level than the latter ( P <0.05).Through the Logistic regression analysis,it was concluded that Hcy was related to the occurrence of incipient diabetic nephropathy.Conclusion Hyperhomocysteinemia is related to the occurrence of incipient diabetic nephropathy,and endothelial dysfuntion may be involved in its pathogenesis.