CAJ | 학술논문

目的　探讨几种新型可生物降解聚酯类合物的结构及生物环境对降解规律的影响，为临床选择应用该类材料提供实验依据. 方法　将自行合成的聚己内酯（PCL）、聚丙交酯（PLA）、以及它们不同摩尔比的共聚物（PCLA2/1, PCLA1/2）分别置于胆汁、胰组织悬液和血浆中1～7 d，植入兔肌肉内24 wk，观察材料质量损失、超微形态变化和分子量变化. 结果　PCL在24 wk内各种性质变化最慢：质量损失不明显，分子质量在胰腺悬液中下降19.8%，形态无明显变化； PCLA2/1在24 wk时质量损失0.5%，分子质量下降61.7%，材料断面出现蚀刻形态；PCLA1/2在24 wk质量损失40.4%，分子质量下降6.6%，形态出现空洞、碎裂；PLA在24 wk质量损失79.2%，分子质量下降15.1%，形态完全降解. 结论　不同结构的材料在不同环境中体现不同的降解性质.
목적　탐토궤충신형가생물강해취지류합물적결구급생물배경대강해규률적영향，위림상선택응용해류재료제공실험의거. 방법　장자행합성적취기내지（PCL）、취병교지（PLA）、이급타문불동마이비적공취물（PCLA2/1, PCLA1/2）분별치우담즙、이조직현액화혈장중1～7 d，식입토기육내24 wk，관찰재료질량손실、초미형태변화화분자량변화. 결과　PCL재24 wk내각충성질변화최만：질량손실불명현，분자질량재이선현액중하강19.8%，형태무명현변화； PCLA2/1재24 wk시질량손실0.5%，분자질량하강61.7%，재료단면출현식각형태；PCLA1/2재24 wk질량손실40.4%，분자질량하강6.6%，형태출현공동、쇄렬；PLA재24 wk질량손실79.2%，분자질량하강15.1%，형태완전강해. 결론　불동결구적재료재불동배경중체현불동적강해성질.
AIM　To examine the effect of molecular structure and the bioenvironmental influence on new-type biodegradable polyesters in order to support the clinical application with laboratorial data. METHODS　Homemade polyesters of variant molecular structures and poly-ε-caprolacton PCL；poly-DL-lactic acid PLA；and two kinds of their copolymer PCLA1/2 and PCLA2/1) were dipped in gall, pancreas suspension and plasma within 1～7 days, planted into muscles of rabbits for 4～24 weeks. Their mass-loss, molecular changes and ultramicromorphology were observed. RESULTS Degradation of PCL was the slowest one. Mass-loss was not obvious: molecular mass of pancreatic suspension lost by 19.8% and no outstanding physical change was observed. PCL2/1 loses mass by 0.5% in 24 wk, and molecular mass loses by 61.7% with etches on cuttings sections. PCLA1/2 loses mass by 40.4 in 24 wk, molecular mass loses by 6.6%, and cracks and holes were observed as the main physical character. PLA lost mass by 79.2% in 24 wk, molecular mass lost by 15.1% and this material was totally degraded. CONCLUSION　Polyester degradation of variant molecular structure is characterized by a distinctivly different properties when in different biotic environment.