临床内科杂志
臨床內科雜誌
림상내과잡지
JOURNAL OF CLINICAL INTERNAL MEDICINE
2009年
5期
349-351
,共3页
汤陵%于世英%丁虎%汤应雄%汪道文%严江涛
湯陵%于世英%丁虎%湯應雄%汪道文%嚴江濤
탕릉%우세영%정호%탕응웅%왕도문%엄강도
肺癌%CYP2J2%EPHX2%基因多态性
肺癌%CYP2J2%EPHX2%基因多態性
폐암%CYP2J2%EPHX2%기인다태성
Lung cancer%CYP2J2%EPHX2%Gene polymorphism
目的 探讨CYP2J2基因启动子区G-50T多态性和EPHX2基因G860A多态性与肺癌发生的关系.方法 经病理检查确诊为肺癌患者150例(肺癌组),300名本院健康体检者作为对照组,检测其CYP2J2基因启动子区G-50T多态性和EPHX2基因G860A多态性,并进行统计学分析.结果 〖JP2〗肺癌组和对照组比较,CYP2J2启动子区G-50T多态性差异无统计学意义,而肺癌组患者EPHX2 860G等位基因频率显著高于对照组人群(96% 比78.3%,P<0.01),多元回归分析方法显示,肺癌的发生与EPHX2 G860A多态性显著相关(校正OR值=0.164,95%CI 0.079～0.342,P<0.001).结论 EPHX2 G860A多态性与肺癌密切相关,可作为肺癌高危患者的预测指标.
目的 探討CYP2J2基因啟動子區G-50T多態性和EPHX2基因G860A多態性與肺癌髮生的關繫.方法 經病理檢查確診為肺癌患者150例(肺癌組),300名本院健康體檢者作為對照組,檢測其CYP2J2基因啟動子區G-50T多態性和EPHX2基因G860A多態性,併進行統計學分析.結果 〖JP2〗肺癌組和對照組比較,CYP2J2啟動子區G-50T多態性差異無統計學意義,而肺癌組患者EPHX2 860G等位基因頻率顯著高于對照組人群(96% 比78.3%,P<0.01),多元迴歸分析方法顯示,肺癌的髮生與EPHX2 G860A多態性顯著相關(校正OR值=0.164,95%CI 0.079～0.342,P<0.001).結論 EPHX2 G860A多態性與肺癌密切相關,可作為肺癌高危患者的預測指標.
목적 탐토CYP2J2기인계동자구G-50T다태성화EPHX2기인G860A다태성여폐암발생적관계.방법 경병리검사학진위폐암환자150례(폐암조),300명본원건강체검자작위대조조,검측기CYP2J2기인계동자구G-50T다태성화EPHX2기인G860A다태성,병진행통계학분석.결과 〖JP2〗폐암조화대조조비교,CYP2J2계동자구G-50T다태성차이무통계학의의,이폐암조환자EPHX2 860G등위기인빈솔현저고우대조조인군(96% 비78.3%,P<0.01),다원회귀분석방법현시,폐암적발생여EPHX2 G860A다태성현저상관(교정OR치=0.164,95%CI 0.079～0.342,P<0.001).결론 EPHX2 G860A다태성여폐암밀절상관,가작위폐암고위환자적예측지표.
Objective To investigate the association between the CYP2J2 gene G-50T and EPHX2 gene G860A polymorphism and lung cancer.Methods One hundred and fifty patients with lung cancer and 300 healthy people as control group were collected.The CYP2J2 gene G-50T and EPHX2 gene G860A polymorphisms were detected and analyzed.Results The allele frequency of EPHX2 gene 860 G in patients with lung cancer was significantly higher than that in control group (96% vs 78.3%,P<0.01).Logistic regression analysis showed that EPHX2 gene G860A polymorphisms was associated to lung cancer significantly(adjusted OR:0.164,95%CI 0.079～0.342,P<0.001).However,there was no significantly association between CYP2J2 gene G-50T polymorphism and lung cancer.Conclusion EPHX2 gene G860A polymorphism is associated with lung cancer,which could become a predictor of lung cancer in high risk population.
