上海精神医学
上海精神醫學
상해정신의학
SHANGHAI ARCHIVES OF PSYCHIATRY
2012年
3期
155-161
,共7页
背景 氧化应激是一种神经毒性因素,可能会促使急性精神病的发生.目的 评估旅途精神病(travel-induced psychosis)与氧化应激的关系.方法 对乘坐长途火车诱发的 21 例旅途精神病住院患者,在其入院时采用简明精神病评定量表(Brief Psychiatric Rating Scale,BPRS)评定精神症状,入院次日清晨测定其血清超氧化物歧化酶(super oxide dlsmutase,SOD)活性和丙二醛(malondialdehyde,MDA)含量;待患者精神病性症状缓解后(通常为小剂量抗精神病药治疗后 2~6天),再次进行上述检测.选取性别、年龄匹配的 21 名健康志愿者为对照组,比较患者与对照者的血清SOD活性和MDA含量.结果 入院时患者的血清SOD活性和MDA含量均高于对照组.精神症状缓解后,患者的BPRS评分、血清SOD活性和MDA含量均显著下降,但后两者仍高于对照组.入院时患者的BPRS总分与SOD活性呈正相关(r=0.32,p=0.164),与MDA含量也呈正相关(r=0.34,p=0.126),但均无统计学意义.治疗后BPRS总分的下降与SOD活性的下降弱相关(r=0.28,p=0.217),也与MDA含量的下降也呈弱相关(r=0.29,p=0.211).结论 研究结果提示,氧化应激的神经毒性作用与旅途精神病的发生直接相关.这或许能够帮助我们理解其他急性精神病性障碍(如精神分裂症)的发生.
揹景 氧化應激是一種神經毒性因素,可能會促使急性精神病的髮生.目的 評估旅途精神病(travel-induced psychosis)與氧化應激的關繫.方法 對乘坐長途火車誘髮的 21 例旅途精神病住院患者,在其入院時採用簡明精神病評定量錶(Brief Psychiatric Rating Scale,BPRS)評定精神癥狀,入院次日清晨測定其血清超氧化物歧化酶(super oxide dlsmutase,SOD)活性和丙二醛(malondialdehyde,MDA)含量;待患者精神病性癥狀緩解後(通常為小劑量抗精神病藥治療後 2~6天),再次進行上述檢測.選取性彆、年齡匹配的 21 名健康誌願者為對照組,比較患者與對照者的血清SOD活性和MDA含量.結果 入院時患者的血清SOD活性和MDA含量均高于對照組.精神癥狀緩解後,患者的BPRS評分、血清SOD活性和MDA含量均顯著下降,但後兩者仍高于對照組.入院時患者的BPRS總分與SOD活性呈正相關(r=0.32,p=0.164),與MDA含量也呈正相關(r=0.34,p=0.126),但均無統計學意義.治療後BPRS總分的下降與SOD活性的下降弱相關(r=0.28,p=0.217),也與MDA含量的下降也呈弱相關(r=0.29,p=0.211).結論 研究結果提示,氧化應激的神經毒性作用與旅途精神病的髮生直接相關.這或許能夠幫助我們理解其他急性精神病性障礙(如精神分裂癥)的髮生.
배경 양화응격시일충신경독성인소,가능회촉사급성정신병적발생.목적 평고려도정신병(travel-induced psychosis)여양화응격적관계.방법 대승좌장도화차유발적 21 례려도정신병주원환자,재기입원시채용간명정신병평정량표(Brief Psychiatric Rating Scale,BPRS)평정정신증상,입원차일청신측정기혈청초양화물기화매(super oxide dlsmutase,SOD)활성화병이철(malondialdehyde,MDA)함량;대환자정신병성증상완해후(통상위소제량항정신병약치료후 2~6천),재차진행상술검측.선취성별、년령필배적 21 명건강지원자위대조조,비교환자여대조자적혈청SOD활성화MDA함량.결과 입원시환자적혈청SOD활성화MDA함량균고우대조조.정신증상완해후,환자적BPRS평분、혈청SOD활성화MDA함량균현저하강,단후량자잉고우대조조.입원시환자적BPRS총분여SOD활성정정상관(r=0.32,p=0.164),여MDA함량야정정상관(r=0.34,p=0.126),단균무통계학의의.치료후BPRS총분적하강여SOD활성적하강약상관(r=0.28,p=0.217),야여MDA함량적하강야정약상관(r=0.29,p=0.211).결론 연구결과제시,양화응격적신경독성작용여려도정신병적발생직접상관.저혹허능구방조아문리해기타급성정신병성장애(여정신분렬증)적발생.
Background: Oxidative stress is a neurotoxic factor that may precipitate acute psychoses.Aim: Assess the relationship of travel-induced psychosis and oxidative stress.Methods: Twenty-one inpatients with travel-induced psychosis related to prolonged train travel were evaluated using the Brief Psychiatric Rating Scale (BPRS) at the time of admission and their plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentrations were assessed on the morning following admission. These assessments were repeated after the psychotic symptoms resolved, which typically occurred after 2-6 days of low-dose antipsychotic treatment. The SOD and MDA results in the patients were compared to those of 21 normal age and gender matched control subjects.Results: At admission the patient group had significantly higher SOD activity and MDA concentrations than the control group. After resolution of the psychotic symptoms the BPRS scores, SOD activity, and MDA concentrations all showed significant declines but the SOD activity and MDA concentrations remained higher than in the matched control group. At admission there was a non-significant positive correlation of the BPRS total score with SOD activity (r=0.32, p=0.164) and with MDA concentration (r=0.34, p=0.126). The before versus after drop in the BPRS total score was weakly correlated with the drop in the SOD activity (r=0.28, p=0.217) and with the drop in the MDA concentration (r=0.29, p=0.211).Conclusion: These findings suggest that the neurotoxic effects of oxidative stress are directly related to the development of travel-induced psychosis. This may be relevant to the understanding of other acute psychotic states such as schizophrenia.
