CAJ | 학술논문

目的探讨消化性溃疡伴幽门螺杆菌(Hp)感染患者干预治疗的临床效果.方法将184例消化性溃疡伴Hp感染患者随机分为两组,常规组给予单纯药物治疗:泮托拉唑和替普瑞酮;干预组给予药物(同上)和生活方式及个人饮食习惯干预治疗;两组疗程均为6周.根除Hp治疗:泮托拉唑加用克拉霉素和阿莫西林,疗程为1周.疗程结束后对比两组疗效.结果临床症状完全缓解时间:干预组中77例第1周完全缓解;常规组中56例第1周完全缓解;两组患者第1周临床症状完全缓解率比较差异有统计学意义(P<0.01).溃疡愈合情况:在疗程结束后胃镜复查显示,干预组90例溃疡治愈,常规组83例溃疡治愈,两组溃疡愈合率比较差异有统计学意义(P<0.05).Hp根除情况:干预组85例,常规组83例,两组比较差异无统计学意义(P>0.05).结论药物结合生活方式及个人饮食习惯的干预治疗能加快临床症状消失,提高溃疡治疗效果.
목적 탐토소화성궤양반유문라간균(Hp)감염환자간예치료적림상효과.방법 장184례소화성궤양반Hp감염환자수궤분위량조,상규조급여단순약물치료:반탁랍서화체보서동;간예조급여약물(동상)화생활방식급개인음식습관간예치료;량조료정균위6주.근제Hp치료:반탁랍서가용극랍매소화아막서림,료정위1주.료정결속후대비량조료효.결과 림상증상완전완해시간:간예조중77례제1주완전완해;상규조중56례제1주완전완해;량조환자제1주림상증상완전완해솔비교차이유통계학의의(P<0.01).궤양유합정황:재료정결속후위경복사현시,간예조90례궤양치유,상규조83례궤양치유,량조궤양유합솔비교차이유통계학의의(P<0.05).Hp근제정황:간예조85례,상규조83례,량조비교차이무통계학의의(P>0.05).결론 약물결합생활방식급개인음식습관적간예치료능가쾌림상증상소실,제고궤양치료효과.
Objective To evaluate the clinical effects of interfered therapy of peptic ulcer with lip. Methods 184 patients were randomly divided into two groups,only durgs were given for conventional treatment group:pan- toprazole and teprenone; the same drugs, the type of life and individual diets were given for interfered treatment group. Therapy time lasted for 6 weeks in two groups. Radical eradication of Hp: pantoprazole plus clarithromycinand amoxycilLin. Results The time. of complete alleviation of clinical symptoms: most of patients in interfered treat- ment group alleviated after one week, half past patients in conventional treatment group alleviated after one week; there were significant difference in alleviation rate of clinical symptoms between two groups( P < 0.01 ). Healing of ulcer:after the end of treatment, all patients underwent endoscopy, most of ulcers healed in interfered treatment group, but 90.22% of ulcers healed in conventional treatment group, there were significant difference in he.sling rate of ulcer between two groups(P< 0.05). Eradicating of Hp: the eradicating of Hp was similar in two groups,there were no significant difference between the interfered treatment group and the conventional treatment group (P > 0.05). Conclusion Through the interfered treatment(drugs combining the type of life and the habit of diet), we can alleviate clinical symptoms and improve the effects of healing of ulcer.