中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
8期
635-637
,共3页
罗雪珍%陈盈珏%徐雯%朱铭伟%林金芳
囉雪珍%陳盈玨%徐雯%硃銘偉%林金芳
라설진%진영각%서문%주명위%림금방
多囊卵巢综合征%口服葡萄糖耐量试验%胰岛素释放试验%胰岛素抵抗%曲线下面积
多囊卵巢綜閤徵%口服葡萄糖耐量試驗%胰島素釋放試驗%胰島素牴抗%麯線下麵積
다낭란소종합정%구복포도당내량시험%이도소석방시험%이도소저항%곡선하면적
Polycystic ovary syndrome%Oral glucose tolerance test%Insulin release test%Insulin resistance%Area under curve
目的 探讨胰岛素释放试验在诊断正常糖耐量的多囊卵巢综合征( PCOS)患者胰岛素抵抗中的价值.方法 对63例PCOS患者进行口服葡萄糖耐量(OGTT)及胰岛素释放试验,正常排卵女性34名作对照.结果 63例PCOS患者,肥胖型(体重指数≥25 kg/m2)为33例,其中5例出现OGTT异常；非肥胖型为30例,OGTT均在正常范围内.采用稳态模型评估的胰岛素抵抗指数(HOMA-IR)及空腹胰岛素水平分析,发现肥胖型PCOS患者、非肥胖型PCOS患者和正常对照组的胰岛素抵抗患病率分别为78.8％、16.7％和9.0％.3组出现胰岛素释放曲线异常分别占84.5％、70.0％和14.7％.对58例OGTT正常的PCOS患者进行分析发现,胰岛素抵抗患病率为44.8％,胰岛素释放曲线异常率为75.9％.其中HOMA-IR及空腹胰岛素正常亚组(n=32)的体重指数与正常对照组无统计学差异[(20.52±2.86对20.01±2.54)kg/m2,P＞0.05].结论 胰岛素释放试验能更敏感反映PCOS患者尤其是非肥胖型患者胰岛素抵抗状态,正常糖耐量PCOS患者普遍存在胰岛素释放亢进现象.
目的 探討胰島素釋放試驗在診斷正常糖耐量的多囊卵巢綜閤徵( PCOS)患者胰島素牴抗中的價值.方法 對63例PCOS患者進行口服葡萄糖耐量(OGTT)及胰島素釋放試驗,正常排卵女性34名作對照.結果 63例PCOS患者,肥胖型(體重指數≥25 kg/m2)為33例,其中5例齣現OGTT異常；非肥胖型為30例,OGTT均在正常範圍內.採用穩態模型評估的胰島素牴抗指數(HOMA-IR)及空腹胰島素水平分析,髮現肥胖型PCOS患者、非肥胖型PCOS患者和正常對照組的胰島素牴抗患病率分彆為78.8％、16.7％和9.0％.3組齣現胰島素釋放麯線異常分彆佔84.5％、70.0％和14.7％.對58例OGTT正常的PCOS患者進行分析髮現,胰島素牴抗患病率為44.8％,胰島素釋放麯線異常率為75.9％.其中HOMA-IR及空腹胰島素正常亞組(n=32)的體重指數與正常對照組無統計學差異[(20.52±2.86對20.01±2.54)kg/m2,P＞0.05].結論 胰島素釋放試驗能更敏感反映PCOS患者尤其是非肥胖型患者胰島素牴抗狀態,正常糖耐量PCOS患者普遍存在胰島素釋放亢進現象.
목적 탐토이도소석방시험재진단정상당내량적다낭란소종합정( PCOS)환자이도소저항중적개치.방법 대63례PCOS환자진행구복포도당내량(OGTT)급이도소석방시험,정상배란녀성34명작대조.결과 63례PCOS환자,비반형(체중지수≥25 kg/m2)위33례,기중5례출현OGTT이상；비비반형위30례,OGTT균재정상범위내.채용은태모형평고적이도소저항지수(HOMA-IR)급공복이도소수평분석,발현비반형PCOS환자、비비반형PCOS환자화정상대조조적이도소저항환병솔분별위78.8％、16.7％화9.0％.3조출현이도소석방곡선이상분별점84.5％、70.0％화14.7％.대58례OGTT정상적PCOS환자진행분석발현,이도소저항환병솔위44.8％,이도소석방곡선이상솔위75.9％.기중HOMA-IR급공복이도소정상아조(n=32)적체중지수여정상대조조무통계학차이[(20.52±2.86대20.01±2.54)kg/m2,P＞0.05].결론 이도소석방시험능경민감반영PCOS환자우기시비비반형환자이도소저항상태,정상당내량PCOS환자보편존재이도소석방항진현상.
Objective To investigate the release pattern of insulin after the load of glucose in patients with polycystic ovary syndrome ( PCOS ) and normal oral glucose tolerance.Methods Sixty-three patients with PCOS were undertaken oral glucose tolerance test (OGTT) and insulin release test,while 34 women with normal menstrual cycle served as control.Results Among 63 patients with PCOS,33 cases were obese with body mass index over 25 kg/m2,including 5 with abnormal OGTT.All 30 non-obese patients with PCOS had normal OGTT.The prevalences of insulin resistance were 78.8％,16.7％,and 9.0％ in obese PCOS,non-obese PCOS,and control groups,respectively.Abnormal insulin release curve were found in 84.5％,70.0％,and 14.7％ of subjects in these 3 groups,respectively.In 58 PCOS patients with normal OGTT,the prevalence of insulin resistance was 44.8％,and 75.9％with abnormal insulin release curve. Among them,body mass index of 32 patients,whose homeostasis model assessment for insulin resistance (HOMA-IR) and fasting insulin remained in normal range,was similar to those of control group [ ( 20.52 ± 2.86 vs 20.01 ± 2.54 ) kg/m2,P＞0.05].Conclusion These findings indicate that insulin release test is useful in detecting insulin resistance.Insulin release is elevated in PCOS patients even with normal OGTT.
