CAJ | 학술논문

目的对新型高能量化合物3,4二呋咱基氧化呋咱(DNTF)的致畸性进行研究,为研究DNTF对人体健康影响和制订职业接触限值提供依据.方法采用大鼠标准致畸试验,将受孕SD大鼠随机分为3个染毒组(剂量分别为5.0、15.8、50.0 mg/kg)、阴性对照组(植物油)和阳性对照组(环磷酰胺10.0 mg/kg),每组10～15只,对孕鼠于孕期7～12d每天灌胃染毒1次,共6d,妊娠第20天处死,检查孕鼠妊娠与胎鼠畸形情况.结果与阴性对照组比较,3个染毒组的孕鼠体重、胎重、胎鼠生长发育、胎鼠畸形率、胎鼠骨骼和内脏畸形率的差异均无统计学意义(P＞0.05).结论 DNTF在5.0～50.0 mg/kg 染毒剂量范围内对大鼠无明显的母体毒性、胚胎毒性和致畸性.
목적 대신형고능양화합물3,4이부찰기양화부찰(DNTF)적치기성진행연구,위연구DNTF대인체건강영향화제정직업접촉한치제공의거.방법 채용대서표준치기시험,장수잉SD대서수궤분위3개염독조(제량분별위5.0、15.8、50.0 mg/kg)、음성대조조(식물유)화양성대조조(배린선알10.0 mg/kg),매조10～15지,대잉서우잉기7～12d매천관위염독1차,공6d,임신제20천처사,검사잉서임신여태서기형정황.결과 여음성대조조비교,3개염독조적잉서체중、태중、태서생장발육、태서기형솔、태서골격화내장기형솔적차이균무통계학의의(P＞0.05).결론 DNTF재5.0～50.0 mg/kg 염독제량범위내대대서무명현적모체독성、배태독성화치기성.
Objective To study the teratogenicity of new high-energy compounds,3,4 two furazanbased oxidation furazan (DNTF) and the impacity on human health,occupational exposure limits were provided for the following research.Methods Pregnant SD rats were randomly divided into five groups by Standard teratogenicity test,including three dose groups (5.0,15.8,50.0 mg/kg),the negative control (vegetable oil),and the positive control group (CP 10.0 mg/kg).Each 10 to 15 rats were in one group.Gavage was consecuted for ratsduringpregnancy 7～12 d and then sacrifice after 20d.Results There were no significantly difference between the three dose groups and negative controls in the pregnancy rate,the weight of pregnant rats,fetal weight,fetal growth,fetal malformation rate and internal organs,Conclusion There were no maternal toxicity,embryo toxicity and teratogenicity for rats when DNTF in the range 5.0～50.0 mg/kg.