中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2010年
12期
987-988
,共2页
脑血管意外%自由基清除剂
腦血管意外%自由基清除劑
뇌혈관의외%자유기청제제
Cerebrovascular accident%Free radical scavengers
目的 探讨依达拉奉清除自由基治疗急性脑梗死的临床疗效.方法 脑梗死患者60例,随机分为治疗组和对照组,两组均常规脱水、降颅压、控制血压等,治疗组用生理盐水250 ml+依达拉奉30 mg静脉滴注,2次/d,连续使用14 d;对照组用生理盐水250 ml,静脉滴注,2次/d,连续使用14d.两组分别于治疗前和治疗后第14 d进行神经功能缺失程度和日常生活活动能力评分(ADL),测定血清超氧化物歧化酶(SOD).结果 治疗组与对照组比较,治疗第14天患者的神经功能缺失程度[(7.5±5.4)分与(15.9±7.9)分,P＜0.05]、ADL得分[(58.32±11.57)分与(43.73±12.48)分,P＜0.05]和血清SOD[(157.25±21.81)mmol/L与(127.08±13.14)mmol/L,P＜0.05]都得到改善,差异均有统计学意义.结论 依达拉奉治疗急性脑梗死可以提高机体清除自由基能力,促进神经功能恢复.
目的 探討依達拉奉清除自由基治療急性腦梗死的臨床療效.方法 腦梗死患者60例,隨機分為治療組和對照組,兩組均常規脫水、降顱壓、控製血壓等,治療組用生理鹽水250 ml+依達拉奉30 mg靜脈滴註,2次/d,連續使用14 d;對照組用生理鹽水250 ml,靜脈滴註,2次/d,連續使用14d.兩組分彆于治療前和治療後第14 d進行神經功能缺失程度和日常生活活動能力評分(ADL),測定血清超氧化物歧化酶(SOD).結果 治療組與對照組比較,治療第14天患者的神經功能缺失程度[(7.5±5.4)分與(15.9±7.9)分,P＜0.05]、ADL得分[(58.32±11.57)分與(43.73±12.48)分,P＜0.05]和血清SOD[(157.25±21.81)mmol/L與(127.08±13.14)mmol/L,P＜0.05]都得到改善,差異均有統計學意義.結論 依達拉奉治療急性腦梗死可以提高機體清除自由基能力,促進神經功能恢複.
목적 탐토의체랍봉청제자유기치료급성뇌경사적림상료효.방법 뇌경사환자60례,수궤분위치료조화대조조,량조균상규탈수、강로압、공제혈압등,치료조용생리염수250 ml+의체랍봉30 mg정맥적주,2차/d,련속사용14 d;대조조용생리염수250 ml,정맥적주,2차/d,련속사용14d.량조분별우치료전화치료후제14 d진행신경공능결실정도화일상생활활동능력평분(ADL),측정혈청초양화물기화매(SOD).결과 치료조여대조조비교,치료제14천환자적신경공능결실정도[(7.5±5.4)분여(15.9±7.9)분,P＜0.05]、ADL득분[(58.32±11.57)분여(43.73±12.48)분,P＜0.05]화혈청SOD[(157.25±21.81)mmol/L여(127.08±13.14)mmol/L,P＜0.05]도득도개선,차이균유통계학의의.결론 의체랍봉치료급성뇌경사가이제고궤체청제자유기능력,촉진신경공능회복.
Objective To investigate the clinical effect of edaravone on free radical damage after acute stroke. Methods The 60 patients with acute stroke were randomly divided into therapy group and control group. Both the groups were treated with routine approaches of dehydration, intracranial pressure reducing and blood pressure control. The treatment with balanced saline 250 ml plus edaravone 30 mg, intravenously infusion twice a day, was adopted in therapy group, while the control group received balanced saline 250 ml only, the treatment lasted for 14 days. Before and 14 days after treatment, the neurologic impairment analysis, activity of daily living scale (ADL) and serum superoxide dismutase (SOD) were checked. Results Compared with control group, after 14 dtreatment, the improvements in neurologic impairment analysis (7.5±5.4 vs. 15.9±7.9, P＜0.05),ADL (58.32±11.57 vs. 43.73± 12.48, P＜0.05) and SOD[(157.25±21.81)mmol/L vs. (127.08 ± 13. 14)mmol/L, P＜0. 05] occurred in therapy group. Conclusions Edaravone could increase the ability of cleaning free radicals and promoting function of nerves recovery.
