中华结核和呼吸杂志
中華結覈和呼吸雜誌
중화결핵화호흡잡지
Chinese Journal of Tuberculosis and Respiratory Diseases
2011年
5期
348-352
,共5页
庞星火%杨鹏%李爽%张莉%田丽丽%李扬%刘博%张奕%刘白薇%黄若刚%黎新宇%王全意
龐星火%楊鵬%李爽%張莉%田麗麗%李颺%劉博%張奕%劉白薇%黃若剛%黎新宇%王全意
방성화%양붕%리상%장리%전려려%리양%류박%장혁%류백미%황약강%려신우%왕전의
流感病毒A型,H1N1亚型%流行病学%接触者追踪
流感病毒A型,H1N1亞型%流行病學%接觸者追蹤
류감병독A형,H1N1아형%류행병학%접촉자추종
Influenza A virus,H1N1 subtype%Epidemiology%Contact tracing
目的 了解和掌握甲型H1N1流感患者密切接触者的流行病学特点,为未来流感大流行的防控提供可参考的依据.方法 选择2009年5月16日至9月15日北京发现的613例具有明确密切接触者信息的甲型H1N1流感患者(原发病例)及其密切接触者7099名作为研究对象,根据其流行病学凋查资料和标本资料收集相关信息,对甲型H1N1流感密切接触者的感染情况进行描述性分析.通过χ2检验对不同类型甲型H1N1流感密切接触者的感染情况进行比较分析.结果 613例原发病例中,男348例(56.8%),女265例(43.2%),年龄为1～75岁,中位年龄为20岁.7099名密切接触者中,男3518名(49.6%),女3514名(49.5%),性别不详67名(0.9%),年龄为0～99岁,中位年龄为27岁.甲型H1N1流感原发病例密切接触者的感染率为2.4%(167/7099).随着密切接触者年龄的增长,甲型H1N1流感病毒感染率呈现明显下降的趋势(χ2=27.87,P＜0.001);以不同方式与原发病例接触的密切接触者之间的感染率比较差异有统计学意义(χ2=109.76,P＜0.001).甲型H1N1流感原发病例的密切接触者中,隐性感染病例占14.4%(24/167).对于密切接触者中出现症状的感染者,最早可在发病前4.5 d的咽拭子标本中检测到病毒;病毒传代时间的中位天数为2.4 d.结论 甲型H1N1流感原发病例密切接触者的病毒感染率较低;不同年龄及不同接触方式的密切接触者之间的感染率存在差异;14.4%的甲型H1N1流感病毒感染者为隐性感染;甲型H1N1流感病例有可能在发病前4.5 d即具有传染性.
目的 瞭解和掌握甲型H1N1流感患者密切接觸者的流行病學特點,為未來流感大流行的防控提供可參攷的依據.方法 選擇2009年5月16日至9月15日北京髮現的613例具有明確密切接觸者信息的甲型H1N1流感患者(原髮病例)及其密切接觸者7099名作為研究對象,根據其流行病學凋查資料和標本資料收集相關信息,對甲型H1N1流感密切接觸者的感染情況進行描述性分析.通過χ2檢驗對不同類型甲型H1N1流感密切接觸者的感染情況進行比較分析.結果 613例原髮病例中,男348例(56.8%),女265例(43.2%),年齡為1～75歲,中位年齡為20歲.7099名密切接觸者中,男3518名(49.6%),女3514名(49.5%),性彆不詳67名(0.9%),年齡為0～99歲,中位年齡為27歲.甲型H1N1流感原髮病例密切接觸者的感染率為2.4%(167/7099).隨著密切接觸者年齡的增長,甲型H1N1流感病毒感染率呈現明顯下降的趨勢(χ2=27.87,P＜0.001);以不同方式與原髮病例接觸的密切接觸者之間的感染率比較差異有統計學意義(χ2=109.76,P＜0.001).甲型H1N1流感原髮病例的密切接觸者中,隱性感染病例佔14.4%(24/167).對于密切接觸者中齣現癥狀的感染者,最早可在髮病前4.5 d的嚥拭子標本中檢測到病毒;病毒傳代時間的中位天數為2.4 d.結論 甲型H1N1流感原髮病例密切接觸者的病毒感染率較低;不同年齡及不同接觸方式的密切接觸者之間的感染率存在差異;14.4%的甲型H1N1流感病毒感染者為隱性感染;甲型H1N1流感病例有可能在髮病前4.5 d即具有傳染性.
목적 료해화장악갑형H1N1류감환자밀절접촉자적류행병학특점,위미래류감대류행적방공제공가삼고적의거.방법 선택2009년5월16일지9월15일북경발현적613례구유명학밀절접촉자신식적갑형H1N1류감환자(원발병례)급기밀절접촉자7099명작위연구대상,근거기류행병학조사자료화표본자료수집상관신식,대갑형H1N1류감밀절접촉자적감염정황진행묘술성분석.통과χ2검험대불동류형갑형H1N1류감밀절접촉자적감염정황진행비교분석.결과 613례원발병례중,남348례(56.8%),녀265례(43.2%),년령위1～75세,중위년령위20세.7099명밀절접촉자중,남3518명(49.6%),녀3514명(49.5%),성별불상67명(0.9%),년령위0～99세,중위년령위27세.갑형H1N1류감원발병례밀절접촉자적감염솔위2.4%(167/7099).수착밀절접촉자년령적증장,갑형H1N1류감병독감염솔정현명현하강적추세(χ2=27.87,P＜0.001);이불동방식여원발병례접촉적밀절접촉자지간적감염솔비교차이유통계학의의(χ2=109.76,P＜0.001).갑형H1N1류감원발병례적밀절접촉자중,은성감염병례점14.4%(24/167).대우밀절접촉자중출현증상적감염자,최조가재발병전4.5 d적인식자표본중검측도병독;병독전대시간적중위천수위2.4 d.결론 갑형H1N1류감원발병례밀절접촉자적병독감염솔교저;불동년령급불동접촉방식적밀절접촉자지간적감염솔존재차이;14.4%적갑형H1N1류감병독감염자위은성감염;갑형H1N1류감병례유가능재발병전4.5 d즉구유전염성.
Objective To examine the epidemiologieal characteristics of infection for close contacts of pandemic(H1N1)2009 and to provide scienlific evidence for preparedness and response for the next pandemic.Methotis A total of 613 index cases with clear information of close contacts and their 7099 close contacts,determined between May 16 and September 15,2009,were inchded in this study.Based on data of epidemioiogical investigation,sampling and test of index cases and close contacts,the characteristics of infection for close contacts were described.Results 56.8%(348/613)of the index cases were male,and 43.2%(265/613)were female,and the median age was 20 years(range:1-75 years).49.6%(3518/7099)of the close contacts were male,and 49.5%(3514/7099)were female,but the sex information of 0.9%(67/7099)could not be recorded.The median age of the close contacts was 27 years(range:0-99 years).2.4%(167/7099)of close contacts were infected.The attack rates decreased with inereasing age of close contacts(χ2=27.87,P＜0.001),and were significantly difierent between various contact patterns of close contact(χ2=109.76,P＜0.001).14.4%of the infected close contacts were asymptomatic.For close contacts with symptomatic infection,vims could be shed 4.5 days before illness onset,and the median generation time was 2.4 days.Conclusion The attack rate of close contacts was very low;and the attack rates were different between various ages and contact patterns of close contacts.In this series 14%of cases with pandemic(H1N1)2009 were asymptomatic.The symptomatic cases might have infectivity 1 day earlier before illness onset.
