中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
25期
1749-1752
,共4页
朱丽%石文静%张淑莲%虞乐萍%姚明珠%施婴婴%曾雪芹%王三南%陈冬梅%林振浪%阮芳箐%黄绮薇%钱燕%陈超
硃麗%石文靜%張淑蓮%虞樂萍%姚明珠%施嬰嬰%曾雪芹%王三南%陳鼕梅%林振浪%阮芳箐%黃綺薇%錢燕%陳超
주려%석문정%장숙련%우악평%요명주%시영영%증설근%왕삼남%진동매%림진랑%원방정%황기미%전연%진초
视网膜病,早产儿%发病率%危险因素%多中心研究
視網膜病,早產兒%髮病率%危險因素%多中心研究
시망막병,조산인%발병솔%위험인소%다중심연구
Retinopathy of prematurity%Incidence%Risk factors%Multicenter studies
目的 通过多中心调查,前瞻性研究早产儿视网膜病(ROP)发病相关危险因素.方法 将2005年1月1日至2006年2月28日在ROP协作网内11家医院出生或收治的出生体重＜2000 g 的早产儿或低出生体重儿纳入研究,按时进行ROP筛查,并记录完整的临床资料,调查ROP发病率,分析相关危险因素.结果 882例早产儿纳入研究,完成ROP随访752例,123例发生ROP (16 4%).ROP组出生时平均胎龄为(30.82±0.20)周,平均出生体重(1430±25)g,平均吸氧时间为(11.6±1.4)d;无ROP组出生时平均胎龄(32.56±0.09)周,平均出生体重(1636±10)g,平均吸氧时间为(4 4±0.3)d.单因素分析提示窒息[相对危险度(RR)=1.462]、吸氧时间＞5 d(RR=2.644)、肺表面活性物质的应用(RR=1.880)、肺炎(RR=2.138)、贫血(RR=3.039)、呼吸窘迫综合征(NRDS,RR=2.325)和酸中毒(RR=1.507)与ROP相关(均P＜0 05),多因素分析提示出生体重[比值比(OR)=0.998]、呼吸暂停(OR=1.653)和输血(OR=1.763)是ROP独立作用的因素(均P＜0.05).结论 在诸多因素中,窒息、吸氧、贫血、NRDS、酸中毒与ROP相关,出生体重、呼吸暂停、输血是ROP独立危险因素.
目的 通過多中心調查,前瞻性研究早產兒視網膜病(ROP)髮病相關危險因素.方法 將2005年1月1日至2006年2月28日在ROP協作網內11傢醫院齣生或收治的齣生體重＜2000 g 的早產兒或低齣生體重兒納入研究,按時進行ROP篩查,併記錄完整的臨床資料,調查ROP髮病率,分析相關危險因素.結果 882例早產兒納入研究,完成ROP隨訪752例,123例髮生ROP (16 4%).ROP組齣生時平均胎齡為(30.82±0.20)週,平均齣生體重(1430±25)g,平均吸氧時間為(11.6±1.4)d;無ROP組齣生時平均胎齡(32.56±0.09)週,平均齣生體重(1636±10)g,平均吸氧時間為(4 4±0.3)d.單因素分析提示窒息[相對危險度(RR)=1.462]、吸氧時間＞5 d(RR=2.644)、肺錶麵活性物質的應用(RR=1.880)、肺炎(RR=2.138)、貧血(RR=3.039)、呼吸窘迫綜閤徵(NRDS,RR=2.325)和痠中毒(RR=1.507)與ROP相關(均P＜0 05),多因素分析提示齣生體重[比值比(OR)=0.998]、呼吸暫停(OR=1.653)和輸血(OR=1.763)是ROP獨立作用的因素(均P＜0.05).結論 在諸多因素中,窒息、吸氧、貧血、NRDS、痠中毒與ROP相關,齣生體重、呼吸暫停、輸血是ROP獨立危險因素.
목적 통과다중심조사,전첨성연구조산인시망막병(ROP)발병상관위험인소.방법 장2005년1월1일지2006년2월28일재ROP협작망내11가의원출생혹수치적출생체중＜2000 g 적조산인혹저출생체중인납입연구,안시진행ROP사사,병기록완정적림상자료,조사ROP발병솔,분석상관위험인소.결과 882례조산인납입연구,완성ROP수방752례,123례발생ROP (16 4%).ROP조출생시평균태령위(30.82±0.20)주,평균출생체중(1430±25)g,평균흡양시간위(11.6±1.4)d;무ROP조출생시평균태령(32.56±0.09)주,평균출생체중(1636±10)g,평균흡양시간위(4 4±0.3)d.단인소분석제시질식[상대위험도(RR)=1.462]、흡양시간＞5 d(RR=2.644)、폐표면활성물질적응용(RR=1.880)、폐염(RR=2.138)、빈혈(RR=3.039)、호흡군박종합정(NRDS,RR=2.325)화산중독(RR=1.507)여ROP상관(균P＜0 05),다인소분석제시출생체중[비치비(OR)=0.998]、호흡잠정(OR=1.653)화수혈(OR=1.763)시ROP독립작용적인소(균P＜0.05).결론 재제다인소중,질식、흡양、빈혈、NRDS、산중독여ROP상관,출생체중、호흡잠정、수혈시ROP독립위험인소.
Objective To evaluate the incidence and risk factors of ROP (retinopathy of prematurity) through a prospective multicenter study. Methods Eleven children's or maternal & child hospitals participated in a collective network. All infants of birth weight＜2000 g, born in or transferred to one of the participating centers from January 1st 2005 to February 28th 2006 were recruited. Timely ophthalmologic examinations were performed. The relevant data at baseline and endpoints were collected at each unit. Results A total of 882 preterm infants fulfilled the screening criteria and 752 finished a follow-up. And 123 infants (16.4%) had some degree of ROP. Infants with ROP had a lower gestational age,birth weight and a longer duration of oxygen versus those without ROP[(30.82±0.20) weeks vs (32.56±0.09) weeks, (1430±25) g vs (1636±10) g, (11.6±1.4) d vs (4.4±0.3)d]. Through a univariate analysis, birth weight, gestational age, asphyxia, oxygen duration＞5 days, apnea, surfactant usage,pneumonia, anemia, blood transfusion, acidosis and neonatal respiratory distress syndrome (NRDS) were associated with ROP (P＜0.05) . Logistic regression analysis showed that birth weight (OR=0.998) ,apnea (OR=1.653) and blood transfusion (OR=1.763) were independent risk factors for ROP.Conclusion Asphyxia, oxygen duration＞5 days, surfactant usage, anemia, acidosis and NRDS, lower birth weight, apnea and blood transfusion may improve the risks of ROP.
