肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
2期
140-143
,共4页
FHIT基因%肺肿瘤%发病机制
FHIT基因%肺腫瘤%髮病機製
FHIT기인%폐종류%발병궤제
FHIT gene%Lung neoplasms%Pathogenesis
脆性组氨酸三联体(FHIT)基因是一种重要的抑癌基因,在非小细胞肺癌(NSCLC)早期和癌前病变中常见到其蛋白缺失,反映了FHIT基因改变是肺癌发生的中早期分子事件.在FHIT蛋白的参与下,促进铁氧化还原蛋白的电子传递功能,促进了癌细胞在氧化应激环境中的凋亡,FHIT蛋白再表达与铂剂联合增强了肿瘤细胞对凋亡的应答.FHIT/FRA3B的异常变化出现早、频率高、检测方便,对阐明人种、遗传多态性、地理因素、生活环境、呼吸疾病等在肺癌发病机制中的影响具有重要的意义.
脆性組氨痠三聯體(FHIT)基因是一種重要的抑癌基因,在非小細胞肺癌(NSCLC)早期和癌前病變中常見到其蛋白缺失,反映瞭FHIT基因改變是肺癌髮生的中早期分子事件.在FHIT蛋白的參與下,促進鐵氧化還原蛋白的電子傳遞功能,促進瞭癌細胞在氧化應激環境中的凋亡,FHIT蛋白再錶達與鉑劑聯閤增彊瞭腫瘤細胞對凋亡的應答.FHIT/FRA3B的異常變化齣現早、頻率高、檢測方便,對闡明人種、遺傳多態性、地理因素、生活環境、呼吸疾病等在肺癌髮病機製中的影響具有重要的意義.
취성조안산삼련체(FHIT)기인시일충중요적억암기인,재비소세포폐암(NSCLC)조기화암전병변중상견도기단백결실,반영료FHIT기인개변시폐암발생적중조기분자사건.재FHIT단백적삼여하,촉진철양화환원단백적전자전체공능,촉진료암세포재양화응격배경중적조망,FHIT단백재표체여박제연합증강료종류세포대조망적응답.FHIT/FRA3B적이상변화출현조、빈솔고、검측방편,대천명인충、유전다태성、지리인소、생활배경、호흡질병등재폐암발병궤제중적영향구유중요적의의.
Fragile histidine triad (FHIT) gene is an important tumor suppressor gene,in non-small-cell lung cancer and precancerous lesions its protein deficiency is common,reflecting the FHIT gene is changing in lung cancer occurred in the early molecular events.Ferredoxin in the participation of Fhit protein promotes the electron transport function,and promotes the apoptosis of tumour cells in oxidative stress environment.Fhit protein expression combined platinum enhanced the apoptosis of tumor cell response.With early occuring,high-frequency and facilitate detection,the abnormal changes of FHIT/FRA3B,which take great significance to explain the factors,such as race,genetic polymorphism,geography,environment,respiratory diseases in the pathogenesis of lung cancer.
