CAJ | 학술논문

目的评价正常肝脏、乙型肝炎后肝硬化、乙型肝炎后肝癌氢质子波谱的表现及意义,探讨消除呼吸运动对肝脏波谱影响的方法.方法使用GE 1.5T磁共振仪单体素定点分辨波谱(PRESS)序列加呼吸门控技术,采集46名受检者肝脏氢质子波谱.根据临床资料、MR征象及病理诊断分为男性健康组(10名)、女性健康组(10名)、男性乙型肝炎后肝硬化组(14例)、男性乙型肝炎后肝癌组(12例).以谷氨酰胺和谷氨酸复合物(Glx)峰高为参照物,判定胆碱峰(Cho)是否升高,分析Cho在各组间的差异. 结果正常男性组Cho峰均低于Glx峰,正常女性组80%Cho峰高于Glx峰,男性乙型肝炎后肝硬化组78.57%Cho峰高于Glx峰,男性乙型肝炎后肝癌组83.33%Cho峰高于Glx峰.正常男女组之间、男性肝硬化组与正常男性组之间、男性肝癌组与正常男性组之间胆碱峰的差异均有统计学意义. 结论正常男性Cho峰低于Glx峰,大部分正常女性Cho峰高于Glx峰,男性乙型肝炎后肝硬化、男性乙型肝炎后肝癌Cho峰升高.使用呼吸门控可以有效地消除呼吸运动对肝脏波谱的影响.
목적 평개정상간장、을형간염후간경화、을형간염후간암경질자파보적표현급의의,탐토소제호흡운동대간장파보영향적방법.방법 사용GE 1.5T자공진의단체소정점분변파보(PRESS)서렬가호흡문공기술,채집46명수검자간장경질자파보.근거림상자료、MR정상급병리진단분위남성건강조(10명)、녀성건강조(10명)、남성을형간염후간경화조(14례)、남성을형간염후간암조(12례).이곡안선알화곡안산복합물(Glx)봉고위삼조물,판정담감봉(Cho)시부승고,분석Cho재각조간적차이. 결과정상남성조Cho봉균저우Glx봉,정상녀성조80%Cho봉고우Glx봉,남성을형간염후간경화조78.57%Cho봉고우Glx봉,남성을형간염후간암조83.33%Cho봉고우Glx봉.정상남녀조지간、남성간경화조여정상남성조지간、남성간암조여정상남성조지간담감봉적차이균유통계학의의. 결론 정상남성Cho봉저우Glx봉,대부분정상녀성Cho봉고우Glx봉,남성을형간염후간경화、남성을형간염후간암Cho봉승고.사용호흡문공가이유효지소제호흡운동대간장파보적영향.
Objective To evaluate the application of 1H-MRS in chronic liver diseases related with hepatitis B, and to investigate the method of eliminating breathing influence to proton MR spectroscopy (1H-MRS) on liver. Methods Liver spectroscopy of 46 subjects were obtained by single-voxel PRESS sequence with respiratory gating with GE 1.5T scanner. The subjects were divided into 4 groups: the normal male group (10 cases), the normal female group (10 cases), the male hepatitis B cirrhosis group (14 cases) and the male liver cancer after hepatitis B group (12 cases) according to clinical data, MR manifestations and pathologic findings. Glutamine and glutamate complex (Glx) peak height served as a reference standard to judge the choline (Cho) peak height. The differences of Cho peak height of each group were compared. Results The peaks of Cho were lower than those of Glx in normal male group. The peaks of Cho were higher than those of Glx in 8 women of normal female group. The peaks of Cho were higher than those of Glx in 11 patients of the male hepatitis B cirrhosis group. The peaks of Cho were higher than those of Glx in 10 patients of the male liver cancer after hepatitis B group. The differences of Cho peak were statistically significant between normal male group and normal female group, the male hepatitis B cirrhosis group and the normal male group, the male liver cancer after hepatitis B group and the normal male group. Conclusion The peaks of Cho in normal males are lower than those of Glx. The peaks of Cho in the majority of normal females are higher than those of Glx. The peaks of Cho increase in male hepatitis B cirrhosis and liver cancer after hepatitis B. Respiratory gating can effectively eliminate the impact of breathing movement on proton MR spectroscopy of liver.