应用化工
應用化工
응용화공
APPLIED CHEMICAL INDUSTRY
2009年
12期
1824-1825
,共2页
孙可一%王平%杨永忠%吴鑫琦%房发俐
孫可一%王平%楊永忠%吳鑫琦%房髮俐
손가일%왕평%양영충%오흠기%방발리
R-(+)-硫代四氢呋喃-2-甲酸%R-(+)-四氢呋喃-2-甲酸%法罗培南
R-(+)-硫代四氫呋喃-2-甲痠%R-(+)-四氫呋喃-2-甲痠%法囉培南
R-(+)-류대사경부남-2-갑산%R-(+)-사경부남-2-갑산%법라배남
R-(+)-thiotetrahydrofuran-2-carboxylic acid%R-(+)-tetrahydrofuran-2-carboxylic acid%faropenem
以R-(+)-四氢呋喃-2-甲酸为原料,通过草酰氯酰化,与NaHS发生取代反应,合成R-(+)-硫代四氢呋喃-2-甲酸,粗品经柱层析,减压蒸馏纯化.产品收率53.3%,产物结构经MS,~1H NMR确认.
以R-(+)-四氫呋喃-2-甲痠為原料,通過草酰氯酰化,與NaHS髮生取代反應,閤成R-(+)-硫代四氫呋喃-2-甲痠,粗品經柱層析,減壓蒸餾純化.產品收率53.3%,產物結構經MS,~1H NMR確認.
이R-(+)-사경부남-2-갑산위원료,통과초선록선화,여NaHS발생취대반응,합성R-(+)-류대사경부남-2-갑산,조품경주층석,감압증류순화.산품수솔53.3%,산물결구경MS,~1H NMR학인.
R-(+)-thiotetrahydrofuran-2-carboxylic acid was synthesized via R-(+)-tetrahydrofuran-2-carboxylic acid by acylation using oxalyl chloride followed by step of substitution reaction using sodium hydrosulfide.The crude product was purified by chromatography column and vacuum distillation.The overall yield was 53.3% and the products was confirmed by MS and ~1H NMR.
