CAJ | 학술논문

目的观察大剂量分割放疗联合多西他赛治疗肺癌骨转移的疗效,探讨相关预后因素.方法对72例明确诊断为肺癌骨转移癌患者进行随机性分组:A组(治疗组:大剂量分割联合多西他赛组,n=36):放疗3.0Gy/次,每周5次,总剂量30Gv.并给予多西他赛联合应用,每次60mg,每周1次,连用2周.B组(对照组:常规剂量分割组,n=36):单纯放射治疗,2.0 Gy/次,每周5次.总剂量40 Gy;所有病例放疗均采用6 MV X射线常规外照射.结果全组病例总有效率为93.1%(67/72),无效6.9%(5/72).A、B组的总有效率各为97.2%(35/36)、88.9%(32/36).放疗结束后,两组间止痛效果(有效率)差异无显著性,但B组起效时间较A组快.结论放射治疗对于骨转移癌的一种有效的对症治疗手段,止痛疗效确切.大剂量分割照射更能快速达到止痛效果.
목적 관찰대제량분할방료연합다서타새치료폐암골전이적료효,탐토상관예후인소.방법 대72례명학진단위폐암골전이암환자진행수궤성분조:A조(치료조:대제량분할연합다서타새조,n=36):방료3.0Gy/차,매주5차,총제량30Gv.병급여다서타새연합응용,매차60mg,매주1차,련용2주.B조(대조조:상규제량분할조,n=36):단순방사치료,2.0 Gy/차,매주5차.총제량40 Gy;소유병례방료균채용6 MV X사선상규외조사.결과 전조병례총유효솔위93.1%(67/72),무효6.9%(5/72).A、B조적총유효솔각위97.2%(35/36)、88.9%(32/36).방료결속후,량조간지통효과(유효솔)차이무현저성,단B조기효시간교A조쾌.결론 방사치료대우골전이암적일충유효적대증치료수단,지통료효학절.대제량분할조사경능쾌속체도지통효과.
Objective To evaluate the efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer and explore the factors related to the prognosis.Methods Seventy-two patients with bone metastasis of lung cancer were divided into group A with hypofractionated radiotherapy at 3.0 Gy/fraction(once a day,5 days per week for 30 Gy)and weekly docetaxel treatment at 60 mg for 2 weeks,and group B with radiotherapy alone at 2.0 Gy/fraction(once a day,5 days per week for 40 Gy).Results The total effective rate was 93.1%(67/72)in these patients,with a non-response rate of 6.9%(5/72).The total effective rate was 97.2%(35/36)in group A and 88.9%(32/36)in group B.After the radiotherapy,the analgesic effect showed no significant difference between the two groups,but the onset of the effect was faster in group B than in group A. Concision Local radiotherapy provides effective pain relief in patients with bone metastasis of lung cancer.High-dose fractionated irradiation can rapidly achieve the analgesic effect.