CAJ | 학술논문

目的评价改良缺血修饰性白蛋白(IMA)测定方法对心肌梗死的早期诊断价值.方法研究84例胸痛病人,其中确诊急性心肌梗死病人43例,胸痛对照组41例,所有病人均在发病6 h内抽血,用改良钴-白蛋白结合法测定缺血修饰性白蛋白,结果用吸光度大小表示;利用ROC曲线来评价IMA诊断AMI的阀值.结果 AMI组IMA吸光度值为(1.195±0.320),胸痛组IMA吸光度为(0.855±0.068),两组差异显著(P<0.001).ROC曲线下的面积为0.947,当阀值为0.906时,其诊断敏感度为93.0%,诊断特异度82.9%.结论利用改良方法测定IMA对急性心肌梗死的早期诊断具有一定的应用价值.
목적 평개개량결혈수식성백단백(IMA)측정방법대심기경사적조기진단개치.방법 연구84례흉통병인,기중학진급성심기경사병인43례,흉통대조조41례,소유병인균재발병6 h내추혈,용개량고-백단백결합법측정결혈수식성백단백,결과용흡광도대소표시;이용ROC곡선래평개IMA진단AMI적벌치.결과 AMI조IMA흡광도치위(1.195±0.320),흉통조IMA흡광도위(0.855±0.068),량조차이현저(P<0.001).ROC곡선하적면적위0.947,당벌치위0.906시,기진단민감도위93.0%,진단특이도82.9%.결론 이용개량방법측정IMA대급성심기경사적조기진단구유일정적응용개치.
Objective To assess the value of an improved ischemia modified albumin (IMA) assay in the diagnosis of early acute myocardial infarction(AMI).Methods Forty-three patients with AMI were enrolled in this study with 41 patients with chest pain serving as the control.Blood samples were obtained from all the patients within 6 h after the onset.IMA was measured by the albumin cobalt binding test and results were presented by absorbance units(ABSU).Receiver operator characteristic curve(ROC curve)was used to evaluate the optimal cut-off value of the assay.Results The mean absorbance in AMI group was obviously higher than that in the control group(1.195±0.320vs 0.855±0.068,P<0.001).The area under the receiver of ROC curve was 0.947,and at the cut-off value of 0.906 ABSU,the sensitivity and specificity of the assay were 93.O%and 82.9%.respectively.Conclusion The improved IMA assay shows good value in early diagnosis of AMI in patients with acute chest pain.