中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
2期
188-190
,共3页
谢宏文%刘树琴%张雪松%刘忠志%庞英
謝宏文%劉樹琴%張雪鬆%劉忠誌%龐英
사굉문%류수금%장설송%류충지%방영
利钠肽,脑/药理学%血管/损伤%C反应蛋白质/药物作用/代谢
利鈉肽,腦/藥理學%血管/損傷%C反應蛋白質/藥物作用/代謝
리납태,뇌/약이학%혈관/손상%C반응단백질/약물작용/대사
Natriuretic peptide,brain/PD%Blood vessels/IN%C-reactive protein/DE/ME
目的 探讨脑利钠肽对损伤的动脉血管壁血管重塑与血清高敏C-反应蛋白水平的影响.方法 将20只雄性新西兰大白兔按随机数字表法分为两组,构建兔髂动脉的球囊损伤模型.术后对照组只喂标准兔饲料,实验组喂标准兔饲料+脑利钠肽0.1 mg/(kg·d),皮下注射20 d.术前、术后4周分别取静脉血查血清C-反应蛋白浓度.术后4周,活体取损伤的动脉组织,制作常规病理切片.采用天地公司TD2000病理图像分析系统测定血管重塑的各项指标.结果 实验组内弹力膜下面积、外弹力膜下面积较对照组增大[(643.2±134.06) μm2 vs(493.7±139.32)μm2;(1495.1±204.98) μm2 vs(1265.9±232.56)μm2,P <0.05].实验组残余管腔面积、面积狭窄率与对照组差异有统计学意义[(519.1±93.47)μm2 vs(308.6±86.50)μm2;(18.68±7.72)μm2 vs (38.04±8.32) μm2,P <0.01].两组中膜面积差异无统计学意义(P>0.05).实验组术后4周血清C-反应蛋白浓度较对照组明显降低.结论 脑利钠肽可改善兔髂动脉球囊损伤后血管重塑,其机制与脑利钠肽抑制炎症反应有关.
目的 探討腦利鈉肽對損傷的動脈血管壁血管重塑與血清高敏C-反應蛋白水平的影響.方法 將20隻雄性新西蘭大白兔按隨機數字錶法分為兩組,構建兔髂動脈的毬囊損傷模型.術後對照組隻餵標準兔飼料,實驗組餵標準兔飼料+腦利鈉肽0.1 mg/(kg·d),皮下註射20 d.術前、術後4週分彆取靜脈血查血清C-反應蛋白濃度.術後4週,活體取損傷的動脈組織,製作常規病理切片.採用天地公司TD2000病理圖像分析繫統測定血管重塑的各項指標.結果 實驗組內彈力膜下麵積、外彈力膜下麵積較對照組增大[(643.2±134.06) μm2 vs(493.7±139.32)μm2;(1495.1±204.98) μm2 vs(1265.9±232.56)μm2,P <0.05].實驗組殘餘管腔麵積、麵積狹窄率與對照組差異有統計學意義[(519.1±93.47)μm2 vs(308.6±86.50)μm2;(18.68±7.72)μm2 vs (38.04±8.32) μm2,P <0.01].兩組中膜麵積差異無統計學意義(P>0.05).實驗組術後4週血清C-反應蛋白濃度較對照組明顯降低.結論 腦利鈉肽可改善兔髂動脈毬囊損傷後血管重塑,其機製與腦利鈉肽抑製炎癥反應有關.
목적 탐토뇌리납태대손상적동맥혈관벽혈관중소여혈청고민C-반응단백수평적영향.방법 장20지웅성신서란대백토안수궤수자표법분위량조,구건토가동맥적구낭손상모형.술후대조조지위표준토사료,실험조위표준토사료+뇌리납태0.1 mg/(kg·d),피하주사20 d.술전、술후4주분별취정맥혈사혈청C-반응단백농도.술후4주,활체취손상적동맥조직,제작상규병리절편.채용천지공사TD2000병리도상분석계통측정혈관중소적각항지표.결과 실험조내탄력막하면적、외탄력막하면적교대조조증대[(643.2±134.06) μm2 vs(493.7±139.32)μm2;(1495.1±204.98) μm2 vs(1265.9±232.56)μm2,P <0.05].실험조잔여관강면적、면적협착솔여대조조차이유통계학의의[(519.1±93.47)μm2 vs(308.6±86.50)μm2;(18.68±7.72)μm2 vs (38.04±8.32) μm2,P <0.01].량조중막면적차이무통계학의의(P>0.05).실험조술후4주혈청C-반응단백농도교대조조명현강저.결론 뇌리납태가개선토가동맥구낭손상후혈관중소,기궤제여뇌리납태억제염증반응유관.
Objective To reveal the relation between rhBNP and vascular remodeling,the relation between rhBNP and levels of serum high sensitive C reactive protein (hs-CRP).Methods 20 male New Zealand rabbits were randomly divided into two groups.All the rabbits were constructed to be models of angioplasty with BC.After injury,the control group were feed with standard forage,the rhBNP group received standard forage plus sibeutaneous rhBNP [0.1mmg/(kg · day),20 days].The rabbits were killed 4weeks after initial injury.The injured segments were dissected free from arteria iliaca externa,processed for histological and morphological study by TD 2000 analysis system of pathology image.The data of vascular remodeling was determined.The levels of hs-CRP were measured at the beginning and the end of the experiment.Results There was significant difference in AUIEM and AUEEM[ (643.2±134.06) μm2 vs (493.7±139.32) μm2 ; (1495.1±204.98)μm2 vs (1265.9±232.56)μm2,P < 0.05 ],extremely significant difference in residual cavity areas and ratios of stenosis[ (519.1±93.47) μm2 vs (308.6±86.50) μm2;(18.68±7.72) μm2 vs (38.04±8.32) μm2,P < 0.01 ].There was no significant difference between the areas of media (P> 0.05).rhBNP reduced the levels of hs-CRP on the 28th day.Conclusions rhBNP can benefit vascular remodeling after angioplasty which might be through its anti -inflammatory action.