CAJ | 학술논문

目的研究不同频率阴部神经电刺激对骶上脊髓损伤犬神经源性膀胱功能障碍的影响. 方法成年比格犬4只,制作骶上脊髓损伤( T9 ～ T10)后神经源性逼尿肌过度活动模型.分别对每只犬进行阴部神经电刺激(5 Hz,20 Hz)；比较刺激前和刺激时的膀胱容量、顺应性、无排尿收缩(NVC)的个数以及排尿效率. 结果阴部神经低频电刺激(5 Hz)可以使膀胱容量和顺应性分别提高(58.9±l7.4)％、(53.1±4.9)％(P＜0.05),逼尿肌过度活动可被明显抑制,NVC数量从刺激前的(1.7±1.3)个减少到(0.9±1.1)个；阴部神经中频电刺激(20 Hz)可以诱发逼尿肌收缩,膀胱排尿效率从(5.8±1.0)％提高到(16.3±2.6)％(P＜0.05). 结论阴部神经低频电刺激能够抑制逼尿肌过度活动,提高膀胱容量和顺应性；阴部神经中频电刺激可以诱发膀胱收缩,提高排尿效率.
목적 연구불동빈솔음부신경전자격대저상척수손상견신경원성방광공능장애적영향. 방법 성년비격견4지,제작저상척수손상( T9 ～ T10)후신경원성핍뇨기과도활동모형.분별대매지견진행음부신경전자격(5 Hz,20 Hz)；비교자격전화자격시적방광용량、순응성、무배뇨수축(NVC)적개수이급배뇨효솔. 결과 음부신경저빈전자격(5 Hz)가이사방광용량화순응성분별제고(58.9±l7.4)％、(53.1±4.9)％(P＜0.05),핍뇨기과도활동가피명현억제,NVC수량종자격전적(1.7±1.3)개감소도(0.9±1.1)개；음부신경중빈전자격(20 Hz)가이유발핍뇨기수축,방광배뇨효솔종(5.8±1.0)％제고도(16.3±2.6)％(P＜0.05). 결론 음부신경저빈전자격능구억제핍뇨기과도활동,제고방광용량화순응성；음부신경중빈전자격가이유발방광수축,제고배뇨효솔.
Objective To determine the effects of pudendal ncrve stimulation with different frequency(5 Hz,20 Hz) on bladder dysfunction dogs after spinal cord injury.Methods The study was done in 4 dogs which chronic spinal cord transection at T9-T10 level.All the dogs underwent electrical stimulation of pudendal nerve (5 Hz,20 Hz).Then,bladder capacity,compliance,non-voiding contraction number (NVC) and voiding efficiency before and during stimulation were compared.Results The bladder capacity and the compliance was increased ( 58.9 ± 17.4) ％ and (53.1 ± 4.9 ) ％ ( P ＜ 0.05 ) by pudendal nerve stimulation with low frequency (5 Hz).Detrusor overactivity can be inhibited and the NVC decreased from 1.7 ± 1.3 to 0.9 ± 1.1.Pudendal nerve stimulation with medium frequency ( 20 Hz) can induce bladder contraction and increased voiding efficiency from (5.8 ± 1.0) ％ to ( 16.3 ± 2.6 ) ％ ( P ＜0.05).Conclusions Pudendal nerve stimulation with low frequency can inhibit detrusor overactivity and increase the bladder capacity and compliance in spinal cord injury dogs.Pudendal nerve stimulation with medium frequency can induce bladder contraction and increased voiding efficicncy.