中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
9期
1060-1061
,共2页
肺心病%葛根素%低分子肝素%超声心动图
肺心病%葛根素%低分子肝素%超聲心動圖
폐심병%갈근소%저분자간소%초성심동도
Pulmonary heart disease%Puerarin%Low-molecular-weight heparin%Echocardiography
目的 应用超声心动图评价葛根素注射液加低分子肝素钙治疗慢性肺源性心脏病(肺心病)急性发作期患者的疗效.方法 将60例肺心病患者完全随机分成研究组(30例)及对照组(30例).对照组采用传统的综合疗法,研究组在对照组的基础上加用葛根素注射液400 mg静脉滴注、1 次/d和低分子肝素钙0.4 ml皮下注射、2次/d,疗程为10 d.治疗前、后使用彩色多普勒超声心动图评价2组患者的右心功能.结果 与治疗前比较,研究组治疗后右心室射血分数增加[(25.0±1.6)%比(40.0±2.3)%,P＜0.01],肺动脉血流加速时间延长[(0.11±0.01)s比(0.14±0.01)s],右心室射血前时间与射血时间的比值降低[(0.650±0.053)比(0.300±0.039),P＜0.01].对照组治疗前后和2组治疗后心功能改变各指标差异均有统计学意义(P＜0.05和P＜0.01)研究组总有效率为93.3%(28/30),对照组总有效率为73.3%(22/30),2组总有效率比较差异有统计学意义(P＜0.05).结论 葛根素加低分子肝素钙能降低肺心病急性发作期患者肺动脉压力,对肺心病右心功能具有明显的恢复作用,疗效满意.
目的 應用超聲心動圖評價葛根素註射液加低分子肝素鈣治療慢性肺源性心髒病(肺心病)急性髮作期患者的療效.方法 將60例肺心病患者完全隨機分成研究組(30例)及對照組(30例).對照組採用傳統的綜閤療法,研究組在對照組的基礎上加用葛根素註射液400 mg靜脈滴註、1 次/d和低分子肝素鈣0.4 ml皮下註射、2次/d,療程為10 d.治療前、後使用綵色多普勒超聲心動圖評價2組患者的右心功能.結果 與治療前比較,研究組治療後右心室射血分數增加[(25.0±1.6)%比(40.0±2.3)%,P＜0.01],肺動脈血流加速時間延長[(0.11±0.01)s比(0.14±0.01)s],右心室射血前時間與射血時間的比值降低[(0.650±0.053)比(0.300±0.039),P＜0.01].對照組治療前後和2組治療後心功能改變各指標差異均有統計學意義(P＜0.05和P＜0.01)研究組總有效率為93.3%(28/30),對照組總有效率為73.3%(22/30),2組總有效率比較差異有統計學意義(P＜0.05).結論 葛根素加低分子肝素鈣能降低肺心病急性髮作期患者肺動脈壓力,對肺心病右心功能具有明顯的恢複作用,療效滿意.
목적 응용초성심동도평개갈근소주사액가저분자간소개치료만성폐원성심장병(폐심병)급성발작기환자적료효.방법 장60례폐심병환자완전수궤분성연구조(30례)급대조조(30례).대조조채용전통적종합요법,연구조재대조조적기출상가용갈근소주사액400 mg정맥적주、1 차/d화저분자간소개0.4 ml피하주사、2차/d,료정위10 d.치료전、후사용채색다보륵초성심동도평개2조환자적우심공능.결과 여치료전비교,연구조치료후우심실사혈분수증가[(25.0±1.6)%비(40.0±2.3)%,P＜0.01],폐동맥혈류가속시간연장[(0.11±0.01)s비(0.14±0.01)s],우심실사혈전시간여사혈시간적비치강저[(0.650±0.053)비(0.300±0.039),P＜0.01].대조조치료전후화2조치료후심공능개변각지표차이균유통계학의의(P＜0.05화P＜0.01)연구조총유효솔위93.3%(28/30),대조조총유효솔위73.3%(22/30),2조총유효솔비교차이유통계학의의(P＜0.05).결론 갈근소가저분자간소개능강저폐심병급성발작기환자폐동맥압력,대폐심병우심공능구유명현적회복작용,료효만의.
Objective To explore the clinical value of low-molecular-weight heparins calcium injection combined with puerarin in treatment of chronic pulmonary heart disease with acute exacerbation by echocardiography. Methods Sixty patients with pulmonary heart disease were randomly divided into experimental and control groups. The control group using the traditional therapy and the experimental group use low-molecular-weight heparins calcium injection combined with puerarin based on the control group. Right ventricular function before and after treatment was evaluated using color Doppler echocardiography. Results Right ventricular ejection fraction was increased by application of low-molecular-weight heparins calcium injection combined with puerarin[(25.0 ± 1.6) %vs (40.0 ± 2.3) %]. Acceleration time (AT) of pulmonary artery extend [(0.11 ± 0.01) s vs (0. 14 ± 0.01) s],and the ratio of the time before the right ventricular ejection (RPEP) and ejection time (RVET) decreased[(0.65 ±0. 053) vs (0.30 ± 0. 039)]. The total effective rate of experimental group was 93.3 % (28/30), and control group was 73.3 % (22/30). It had significantly different (P ＜ 0.05). Conclusion Low-molecular-weight heparins calcium injection combined with puerarin can reduce pulmonary arterial pressure of pulmonary heart disease, and the right ventricular function recovers significantly.
