CAJ | 학술논문

目的探讨老年患者喉罩放置时依托咪酯乳剂的合适剂量.方法行择期喉罩全麻下手术的老年患者(年龄>65岁)75例,随机均分为五组:静注芬太尼1μg/kg后,分别静注依托咪酯乳剂0.2 mg/kg(Ⅰ组)、0.25 mg/ks(Ⅱ组)、0.3 mg/kg(Ⅲ组)、0.35 mg/kg(Ⅳ组)、0.4 mg/kg(Ⅴ组),固定由1名麻醉医师放置喉罩.放置喉罩时,患者出现吞咽、呛咳、屏气、喉痉挛等任何气道反应或肢体运动,均认为喉罩置入阳性反应.结果联合应用芬太尼1μg/kg,依托咪酯的50%有效剂量(ED_(50))为0.24 mg/kg(95%的可信区间为0.21～0.26 mg/kg),95%有效剂量(ED_(95))为0.35mg/kg(95%的可信区间为0.31～0.44 mg/kg).结论依托咪酯乳剂0.35 mg/kg复合芬太尼1μg/kg静脉麻醉诱导用于老年患者喉罩放置,血流动力学稳定,不良反应少见.
목적 탐토노년환자후조방치시의탁미지유제적합괄제량.방법 행택기후조전마하수술적노년환자(년령>65세)75례,수궤균분위오조:정주분태니1μg/kg후,분별정주의탁미지유제0.2 mg/kg(Ⅰ조)、0.25 mg/ks(Ⅱ조)、0.3 mg/kg(Ⅲ조)、0.35 mg/kg(Ⅳ조)、0.4 mg/kg(Ⅴ조),고정유1명마취의사방치후조.방치후조시,환자출현탄인、창해、병기、후경련등임하기도반응혹지체운동,균인위후조치입양성반응.결과 연합응용분태니1μg/kg,의탁미지적50%유효제량(ED_(50))위0.24 mg/kg(95%적가신구간위0.21～0.26 mg/kg),95%유효제량(ED_(95))위0.35mg/kg(95%적가신구간위0.31～0.44 mg/kg).결론 의탁미지유제0.35 mg/kg복합분태니1μg/kg정맥마취유도용우노년환자후조방치,혈류동역학은정,불량반응소견.
Objective To determine the optimal dose of etomidate-lipuro required for the successful insertion of laryngeal mask airway(LMA) in the elderly. Methods Seventy-five patients aged greater than 65 years old scheduled for selective minor surgery were recruited. After fentanyl 1 μg/kg was administered intravenously, they were randomly received one of five dodges (0. 2,0. 25, 0. 3,0. 35 and 0. 4 mg/kg) of etomidate-lipuro. The successful insertion of LMA was defined as the absence of gross purposeful movement, coughing, gagging or laryngospasm after LMA insertion. Results Combined with fentanyl 1μg/kg, the ED_(50) and ED_(95) values of etomidate-lipuro for LMA insertion were 0. 24 mg/kg (95% confidence intervals, 0. 21-0. 26 mg/kg) and 0. 35 mg/kg (95% confidence intervals,0. 31-0. 44 mg/kg), respectively. Conclutsion Combined with fentanyl 1μg/kg, the optimum dose of etomidate-lipuro for LMA insertion in the elderly is 0. 35 mg/kg.