CAJ | 학술논문

系统性红斑狼疮是一种累及全身多器官系统的自身免疫性疾病,其发病机制尚不明确.表观遗传学是指发生在基因表达水平的可遗传的变化,但不涉及基因序列的改变.其涉及的机制主要有DNA甲基化、组蛋白修饰、microRNA等.研究显示,表观遗传学异常与系统性红斑狼疮发病密切相关.主要阐述DNA甲基化、组蛋白修饰和microRNA在系统性红斑狼疮发病中的作用.
계통성홍반랑창시일충루급전신다기관계통적자신면역성질병,기발병궤제상불명학.표관유전학시지발생재기인표체수평적가유전적변화,단불섭급기인서렬적개변.기섭급적궤제주요유DNA갑기화、조단백수식、microRNA등.연구현시,표관유전학이상여계통성홍반랑창발병밀절상관.주요천술DNA갑기화、조단백수식화microRNA재계통성홍반랑창발병중적작용.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with the involvement of multiple organ systems.The pathogenesis remains largely unknown.Epigenetics refers to stable and heritable changes in gene expression without changes in underlying DNA sequence.The major epigenetic mechanisms include DNA methylation,histone modification and microRNA.Many studies have shown that epigenetic abnormalities are closely correlated with the pathogenesis of SLE.This review describes the roles of DNA methylation,histone modification and microRNA in the pathogenesis of SLE.