CAJ | 학술논문

目的探讨APACHE Ⅱ评分大于23的重症MODS患者血清VCAM-1、TNF-α等炎症因子之间及其与APACHE评分之间的关系,为临床判断患者预后、寻求有效的治疗方法提供依据.方法收集APACHE Ⅱ评分大于23的重症MODS患者血清,用ELISA的方法检测患者血清VCAM-1、TNF-α水平,并对患者行APACHE Ⅱ评分.结果 1重症MODS患者血清VCAM-1及,INF-α均明显升高,而且二者明显正相关关系(r=0.395,P=0.012).2 VCAM-1及TNF-α与APACHE Ⅱ评分明显相关,尤以VCAM-1为著(r分别为0.526,0.227,P均小于0.05).结论内皮细胞的损伤可能是导致MODS晚期炎症因子增高的重要原因;内皮细胞的损伤参与了MODS的发生发展;VCAM-1可作为评价重症MODS患者严重程度的指标.
목적 탐토APACHE Ⅱ평분대우23적중증MODS환자혈청VCAM-1、TNF-α등염증인자지간급기여APACHE평분지간적관계,위림상판단환자예후、심구유효적치료방법 제공의거.방법 수집APACHE Ⅱ평분대우23적중증MODS환자혈청,용ELISA적방법 검측환자혈청VCAM-1、TNF-α수평,병대환자행APACHE Ⅱ평분.결과 1중증MODS환자혈청VCAM-1급,INF-α균명현승고,이차이자명현정상관관계(r=0.395,P=0.012).2 VCAM-1급TNF-α여APACHE Ⅱ평분명현상관,우이VCAM-1위저(r분별위0.526,0.227,P균소우0.05).결론 내피세포적손상가능시도치MODS만기염증인자증고적중요원인;내피세포적손상삼여료MODS적발생발전;VCAM-1가작위평개중증MODS환자엄중정도적지표.
Objective To explore, the relationship among the level of VCAM-1 and TNF-α and APACHE Ⅱ score in severe MODS patients whose APACHE Ⅱ score was more than 23. Methods VCAM-1 and TNF-α level were detected with ELISA method, and the APACHE Ⅱ score of patients were counted up. Results The level of VCAM-1 and TNF-α of severe MODS patients were significantly raised, and has significantly positive correlation (r=0.395, P=0.012). The level of VCAM-1, TNF-α and APACHE Ⅱ score were significandy correlated, particularly VCAM-1 (r was 0.227 and 0.526 respectively, P<0.05). Conclusions VCAM-1 can be used as a severity index of patients with MODS.