CAJ | 학술논문

目的探讨大肠癌组织中Survivin的表达及其与肿瘤血管生成的关系.方法采用免疫组化SP法,检测51例大肠癌组织、16例腺瘤组织和16例大肠正常组织中Survivin的表达及微血管密度(microvessel densi-ty,MVD).结果大肠癌组织中Survivin、微血管密度的表达远高于腺瘤和正常组织(P<0.05).大肠癌中Sur-vivin的表达及微血管密度与肿瘤的部位无关(P>0.05),而与Dukes分期、浸润深度、淋巴结转移及远处转移密切相关(P<0.05).Survivin的表达与微血管密度显著相关(P<0.05).结论 Survivin在大肠癌的发生和发展中起重要作用,并与肿瘤血管生成有关.
목적 탐토대장암조직중Survivin적표체급기여종류혈관생성적관계.방법 채용면역조화SP법,검측51례대장암조직、16례선류조직화16례대장정상조직중Survivin적표체급미혈관밀도(microvessel densi-ty,MVD).결과대장암조직중Survivin、미혈관밀도적표체원고우선류화정상조직(P<0.05).대장암중Sur-vivin적표체급미혈관밀도여종류적부위무관(P>0.05),이여Dukes분기、침윤심도、림파결전이급원처전이밀절상관(P<0.05).Survivin적표체여미혈관밀도현저상관(P<0.05).결론 Survivin재대장암적발생화발전중기중요작용,병여종류혈관생성유관.
Objective To investigate the significance of Survivin expression and tumor angiogen-esis for colorectal carcinoma tissue. Methods Survivin expression and microvessel density were detected with immunochemical SP method in 51 cases of coloreetal carcinoma, 16 cases of adenoma and 16 cases of normal tissue. Results The positive rates of Survivin and microvessel density in colorectal carcinoma were significantly higher than those in adenoma and normal tissue(P <0.05). Survivin and microvessel density had no significant correlation with tumor site in colorectal carcinoma, but had significant correla-tion with Dukes stage, depth of invasion, lymphnode metastasis and distant metastasis. Survivin expres-sion was correlated with microvessel density. Conclusions Survivin play a key role in the development of coloreetal carcinoma, and correlate with the tumor angiogenesis.