肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
1期
26-28
,共3页
子宫颈肿瘤%放射疗法%药物疗法%预后
子宮頸腫瘤%放射療法%藥物療法%預後
자궁경종류%방사요법%약물요법%예후
Uterine cervical neoplasms%Radiotherapy%Drug therapy%Prognosis
目的 比较放疗期间增敏化疗和单纯放射治疗中、晚期子宫颈癌的疗效及不良反应.方法 65例中、晚期子宫颈癌患者被随机分为治疗组(33例)和对照组(32例).治疗组在放疔期间加增敏化疗2个疗程,在放疗的第1个周期开始PF方案(顺铂+5-氟尿嘧啶)化疗,放疗4～6周后,再行第2个疗程的化疗.对照组单纯进行放疗.结果 治疗组和对照组的近期有效率分别为100%和91%;治疗组1、2年生存率分别为80%、66%;对照组1、2年生存率分别为73%、31%;局部复发率分别为9%和31%;两组患者的不良反应均为白细胞减少、放射性直肠炎和放射性膀胱炎,其发生率近似.但Ⅲ～Ⅳ度血液反应发生率分别为12%和9%.结论 放疗期间加2个疗程的增敏化疗对子宫颈癌具有较好的疗效.
目的 比較放療期間增敏化療和單純放射治療中、晚期子宮頸癌的療效及不良反應.方法 65例中、晚期子宮頸癌患者被隨機分為治療組(33例)和對照組(32例).治療組在放疔期間加增敏化療2箇療程,在放療的第1箇週期開始PF方案(順鉑+5-氟尿嘧啶)化療,放療4～6週後,再行第2箇療程的化療.對照組單純進行放療.結果 治療組和對照組的近期有效率分彆為100%和91%;治療組1、2年生存率分彆為80%、66%;對照組1、2年生存率分彆為73%、31%;跼部複髮率分彆為9%和31%;兩組患者的不良反應均為白細胞減少、放射性直腸炎和放射性膀胱炎,其髮生率近似.但Ⅲ～Ⅳ度血液反應髮生率分彆為12%和9%.結論 放療期間加2箇療程的增敏化療對子宮頸癌具有較好的療效.
목적 비교방료기간증민화료화단순방사치료중、만기자궁경암적료효급불량반응.방법 65례중、만기자궁경암환자피수궤분위치료조(33례)화대조조(32례).치료조재방정기간가증민화료2개료정,재방료적제1개주기개시PF방안(순박+5-불뇨밀정)화료,방료4～6주후,재행제2개료정적화료.대조조단순진행방료.결과 치료조화대조조적근기유효솔분별위100%화91%;치료조1、2년생존솔분별위80%、66%;대조조1、2년생존솔분별위73%、31%;국부복발솔분별위9%화31%;량조환자적불량반응균위백세포감소、방사성직장염화방사성방광염,기발생솔근사.단Ⅲ～Ⅳ도혈액반응발생솔분별위12%화9%.결론 방료기간가2개료정적증민화료대자궁경암구유교호적료효.
Objective To Compare the effect and side effect of middle and advanced cervical cancer between sensitizing chemotherapy and radiotherapy. Methods 65 cervical cancer patients were randomly divided into two set: treatment (33) and comparison (32). During radiotherapy, the treatment set was added two courses of sensitizing chemotherapy, where the first one began the first radiotherapy week and the second one began after four-to-six weeks. The chemotherapy scheme was PF. The comparison set only received radiotherapy. Results The short effective rate of treatment set and comparison set was 100 % and 91% respectively, and one year survival rate of them was 80 % and 66 %, two year 73 % and 31 %, the local recurrent rate 9 % and 31 %. Grade 3-4 acute leucopenia rate was 9 % and 13 %. The side effects of two sets were white blood cells decrease, radiation pmctitis and radiocystitis, and these results were similar. Conclusion The method of two cycles sensitizing chemotherapy during radiotherapy has better treatment effect for cervical cancer.
