CAJ | 학술논문

提出了可分析、筛选乳胶微粒的介电泳陷阱与微马达,并以此为核心单元讨论了片上实验室的组建.设计了可集中样本预处理、分离筛选与微马达驱动等多个功能于一体的微分析芯片,并优化了各分立单元的作用效果.用新的螺旋-叉指和螺旋-城堡电极代替传统的螺旋状或者叉指、城堡状电极,可以不必借助电渗流的作用分开大小不同的乳胶微粒,分离效率达90%以上.当激励信号为驻波时,样本分离电压比普遍使用的行波信号降低50%.对于起介电泳筛选作用的城堡状电极进行了侧向和轴向的非均匀化处理,提高了对微粒尺寸的敏感性,可以将70%的小微粒从混合液中分离.有限元分析和实验结果表明,与参考文献中提到的芯片结构相比,电极的新排布方式增加了轴向场强梯度,分离电压比传统方法降低了80%.另外,微马达和探测电极的集成,为旋转性质的测电学量提供了便利.
제출료가분석、사선유효미립적개전영함정여미마체,병이차위핵심단원토론료편상실험실적조건.설계료가집중양본예처리、분리사선여미마체구동등다개공능우일체적미분석심편,병우화료각분립단원적작용효과.용신적라선-차지화라선-성보전겁대체전통적라선상혹자차지、성보상전겁,가이불필차조전삼류적작용분개대소불동적유효미립,분리효솔체90%이상.당격려신호위주파시,양본분리전압비보편사용적행파신호강저50%.대우기개전영사선작용적성보상전겁진행료측향화축향적비균균화처리,제고료대미립척촌적민감성,가이장70%적소미립종혼합액중분리.유한원분석화실험결과표명,여삼고문헌중제도적심편결구상비,전겁적신배포방식증가료축향장강제도,분리전압비전통방법강저료80%.령외,미마체화탐측전겁적집성,위선전성질적측전학량제공료편리.
This paper reports dielectrophoretic traps and a micro-motor for driving and sorting latex spheres on a chip with complex structures. A scheme containing function modules for pre-separating, sorting and drivingmicro-particles in a single chip is proposed. In order to optimize the system design, comparative researches on various electrode geometries of discrete devices from different separation principles are undertaken. Different from the obtained results before,the electrode shapes of all parts have been modified,which makes the dielectrophoresis effects better than those of traditional approaches. Moreover,a novel spiral interdigital or a spiral-castle electrode is used to replace the old spiral electrodes, and more than 90% target particles can be obtained. The separation voltage signal also can be decreased by 50% while using a standing wave instead of a conventional traveling wave. Other wise,the lateral or axial inhomogeneously castellated electrode is constructed, by which 70% target particles can be sorted. Moreover, for the dielectrophoretic micro-motor composed of a coplanar and quadrupolar electrode structure, it is observed that annular array shaped electrodes in the center can make the device obtain high rotation speed under a low voltage condition.