CAJ | 학술논문

目的探讨女性生殖道人乳头瘤病毒(HPV)各种基因分型感染的情况.方法采用HPV分型基因芯片检测系统,同时检测5种低危型HPV亚型和18种高危型HPV亚型.结果测定250例标本中HPV阳性92例(36.8 %),20～35岁的年龄阶段检出率最高(占总阳性数73.9%),其中感染单一亚型57例(61.9%),感染2种亚型28例(30.4%),感染3种亚型及以上7例.低危型主要为HPV6、11,其次为43;高危型主要为16、18、33、35、45、31、58等亚型.结论基因芯片对于检测HPV的多种型别和HPV多型别混合感染具有重要意义,可为HPV感染和宫颈癌的防治提供重要依据.
목적 탐토녀성생식도인유두류병독(HPV)각충기인분형감염적정황.방법 채용HPV분형기인심편검측계통,동시검측5충저위형HPV아형화18충고위형HPV아형.결과 측정250례표본중HPV양성92례(36.8 %),20～35세적년령계단검출솔최고(점총양성수73.9%),기중감염단일아형57례(61.9%),감염2충아형28례(30.4%),감염3충아형급이상7례.저위형주요위HPV6、11,기차위43;고위형주요위16、18、33、35、45、31、58등아형.결론 기인심편대우검측HPV적다충형별화HPV다형별혼합감염구유중요의의,가위HPV감염화궁경암적방치제공중요의거.
Objective To investigate various types of human papilloma virus (HPV) infection involving female reproductive tract. Methods HPV genotyping gene chip detection system was employed to detect 5 subtypes of low risk HPVs and 18 high risk ones, respectively. Results Of 250samples, 92 were HPV positive (36. 8%). The detection rate was highest among 20-35 year-old women (accounting for 73.9% of positive samples). Among them, 57 cases had one sub-type infection (61.9%), 28 cases had 2 subtypes infection (30.4%) and 7 cases with no less than 3 sub-types infection. Most low risk sub-types were HPV 6, 11 followed by HPV 43 while high risk subtypes included HPV 16, 18, 33, 35, 45, 31, 58, and so on. Conclusion Gene chip assay contributed to detection of various HPV subtypes and HPV multi-infection, and provides basis for prevention and cure of HPV infection and uterine cervix cancer.