CAJ | 학술논문

目的探讨吡格列酮对无胰岛素抵抗的原发性高血压患者左心室肥厚及炎性因子的影响.方法选择无胰岛素抵抗的原发性高血压伴左心室肥厚患者60例,随机分成吡格列酮组与常规治疗组.常规治疗组给予依那普利治疗,吡格列酮组给予依那普利和吡格列酮治疗,均治疗6个月.比较两组患者治疗前后左心室质量指数(LVMI)、血清肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)和白介素6(IL-6)的变化水平.结果吡格列酮组与常规治疗组患者治疗前LVMI、血清TNF-α、IL-1β、IL-6的水平比较,差异均无统计学意义(P＞0.05),两组患者治疗后LVMI、血清TNF-α、IL-1β、IL-6的水平比较,差异均有统计学意义(P＜0.05).结论吡格列酮能通过抗炎作用逆转原发性高血压左心室肥厚.
목적 탐토필격렬동대무이도소저항적원발성고혈압환자좌심실비후급염성인자적영향.방법 선택무이도소저항적원발성고혈압반좌심실비후환자60례,수궤분성필격렬동조여상규치료조.상규치료조급여의나보리치료,필격렬동조급여의나보리화필격렬동치료,균치료6개월.비교량조환자치료전후좌심실질량지수(LVMI)、혈청종류배사인자α(TNF-α)、백개소1β(IL-1β)화백개소6(IL-6)적변화수평.결과 필격렬동조여상규치료조환자치료전LVMI、혈청TNF-α、IL-1β、IL-6적수평비교,차이균무통계학의의(P＞0.05),량조환자치료후LVMI、혈청TNF-α、IL-1β、IL-6적수평비교,차이균유통계학의의(P＜0.05).결론 필격렬동능통과항염작용역전원발성고혈압좌심실비후.
Objective To investigate the effect of Pioglitazone on left ventricular hypertrophy and inflammatory factors in patients with primary hypertension and without insulin resistance.Methods Totally 60 primary hypertension patients without insulin resistance were randomly divided as trial group and control group.The patients in the control group were treated with Enalapril,while those in the trial group with Enalapril plus Pioglitazone for 6 months.The changes of left ventricular mass index (LVMI),serum tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β) and interleukin-6 (IL-6) were compared between the two groups before and after treatment.Results There was no significant difference between the two groups in levels of LVMI,serum TNF-α,IL-1β,and IL-6 decreased before the treatment(P＞0.05);however,after the treatment there were (P＜0.05).Conclusion Pioglitazone can reverse left ventricular hypertrophy in primary hypertension by its anti-inflammatory action.