国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
1期
52-56
,共5页
复方枸橼酸阿尔维林胶囊%酪酸梭菌活菌胶囊%匹维溴铵%肠易激综合征
複方枸櫞痠阿爾維林膠囊%酪痠梭菌活菌膠囊%匹維溴銨%腸易激綜閤徵
복방구연산아이유림효낭%락산사균활균효낭%필유추안%장역격종합정
Compound alverine citrate%Meteospasmyl%Clostridium butyricum%Pinaverium bromide%Irritable bowel syndrome
目的 观察复方枸橼酸阿尔维林胶囊合用酪酸梭菌活菌胶囊治疗肠易激综合征的近期疗效.方法 采用随机对照方法 ,将81例IBS病人随机分成A组和B组,A组病例给予复方枸橼酸阿尔维林软胶囊1粒,每日3次;B组给予匹维溴铵片50mg,每日3次.两组都口服酪酸梭菌活菌胶囊1.26g,每日2次.分别于第2周末和第4周末观察病人腹痛、腹胀、腹泻、便秘等情况,并据此评价各组的疗效.结果 第2周末疗效评定,A组和B组的总有效率分别为70.7%和65.0%,差别没有显著性差异(P>0.05);第4周末疗效评定,两组总有效率分别为88.6%和81.8%(P>0.05).就单项症状而言,第2周末对腹痛、腹泻的疗效,两组差别无显著意义(P>0.05);对腹胀的疗效A组明显优于B组(P<0.01);对便秘B组优于A组但差异无统计学意义(P>0.05).第4周末四种症状的疗效均无显著性差异(P>0.05);3、第4周末A、B两组总有效率高于第2周末,但是差异无显著性意义.结论 复方枸橼酸阿尔维林合用酪酸梭菌活菌胶囊可以有效缓解IBS病人的临床症状,近期疗效明显.治疗需要一定的疗程,4周疗程比2周疗程效果好.
目的 觀察複方枸櫞痠阿爾維林膠囊閤用酪痠梭菌活菌膠囊治療腸易激綜閤徵的近期療效.方法 採用隨機對照方法 ,將81例IBS病人隨機分成A組和B組,A組病例給予複方枸櫞痠阿爾維林軟膠囊1粒,每日3次;B組給予匹維溴銨片50mg,每日3次.兩組都口服酪痠梭菌活菌膠囊1.26g,每日2次.分彆于第2週末和第4週末觀察病人腹痛、腹脹、腹瀉、便祕等情況,併據此評價各組的療效.結果 第2週末療效評定,A組和B組的總有效率分彆為70.7%和65.0%,差彆沒有顯著性差異(P>0.05);第4週末療效評定,兩組總有效率分彆為88.6%和81.8%(P>0.05).就單項癥狀而言,第2週末對腹痛、腹瀉的療效,兩組差彆無顯著意義(P>0.05);對腹脹的療效A組明顯優于B組(P<0.01);對便祕B組優于A組但差異無統計學意義(P>0.05).第4週末四種癥狀的療效均無顯著性差異(P>0.05);3、第4週末A、B兩組總有效率高于第2週末,但是差異無顯著性意義.結論 複方枸櫞痠阿爾維林閤用酪痠梭菌活菌膠囊可以有效緩解IBS病人的臨床癥狀,近期療效明顯.治療需要一定的療程,4週療程比2週療程效果好.
목적 관찰복방구연산아이유림효낭합용락산사균활균효낭치료장역격종합정적근기료효.방법 채용수궤대조방법 ,장81례IBS병인수궤분성A조화B조,A조병례급여복방구연산아이유림연효낭1립,매일3차;B조급여필유추안편50mg,매일3차.량조도구복락산사균활균효낭1.26g,매일2차.분별우제2주말화제4주말관찰병인복통、복창、복사、편비등정황,병거차평개각조적료효.결과 제2주말료효평정,A조화B조적총유효솔분별위70.7%화65.0%,차별몰유현저성차이(P>0.05);제4주말료효평정,량조총유효솔분별위88.6%화81.8%(P>0.05).취단항증상이언,제2주말대복통、복사적료효,량조차별무현저의의(P>0.05);대복창적료효A조명현우우B조(P<0.01);대편비B조우우A조단차이무통계학의의(P>0.05).제4주말사충증상적료효균무현저성차이(P>0.05);3、제4주말A、B량조총유효솔고우제2주말,단시차이무현저성의의.결론 복방구연산아이유림합용락산사균활균효낭가이유효완해IBS병인적림상증상,근기료효명현.치료수요일정적료정,4주료정비2주료정효과호.
Objective To observe and evaluate the efficacy of compound alverine citrate with capsule of clostridium butyricum live in the treatment of IBS. Methods 81 patients with IBS were divided into 2 groups randomly. Patients in group A (41 cases) were treated orally with capsule of compound alverine citrate (Meteospasmyl, one capsule, 3 times a day) and capsule of clostridium butyricum live (Ataining, 1.26, twice a day),while those in group B (40 cases) were given orally pinaverium bromide (Dicetel, 50 mg, 3 times a day) for 4 weeks. A observation and evaluation on the change of such symptoms as abdominal pain, abdominal bulge, diarrhea, or constipation was performed respectively at the end of 2nd and 4th week of therapeutic period. Results The total effective rates were 70.7% and 88.6% at the end of 2nd and 4th week of the medication period respectively in group A, and those in group B were 65.0% and 81.8% simultaneously. There was no significant difference (P>0.05) between the efficacy of group A and B, neither after 2 weeks' treatment nor after 4 weeks' treatment. However, at 2nd week, the improvement of abdominal bulge symptom in group A was better than in group B (P<0.01). Conclusions Compound alverine citrate and capsule of clostridium butyricum live can be used in the treatment of IBS with a definite therapeutic effect.
