中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
1期
14-15
,共2页
马建林%林劲%吴忠%黄白丽%王圣%苏哲坦%王天松%李斌%陈关良%王卫
馬建林%林勁%吳忠%黃白麗%王聖%囌哲坦%王天鬆%李斌%陳關良%王衛
마건림%림경%오충%황백려%왕골%소철탄%왕천송%리빈%진관량%왕위
不稳定心绞痛%分子标记物%膜糖蛋白%凝血
不穩定心絞痛%分子標記物%膜糖蛋白%凝血
불은정심교통%분자표기물%막당단백%응혈
Unstable angina pactoris%Molecular marker%Membrane glycoprotein%Blood coagulation
目的 观察老年不稳定型心绞痛(UAP)患者体内血液止、凝血分子标记物水平的变化并探讨其临床意义.方法 将42例老年UAP患者作为病例组,18例健康者作为对照组,分别测定2组血清血管性血友病因子、抗凝血酶Ⅲ、纤溶酶原、血浆血小板颗粒膜糖蛋白-140、血浆纤维蛋白原、D-二聚体含量以及血小板膜糖蛋白分子数,并进行统计学分析.结果 病例组血小板膜糖蛋白分子数较对照组明显增多(P＜0.05或P＜0.01).病例组血管性血友病因子、血浆血小板颗粒膜糖蛋白-140、血浆纤维蛋白原、D-二聚体水平较对照组明显增加(P＜0.05或P＜0.01),而抗凝血酶Ⅲ则明显降低(P＜0.01);纤溶酶原含量病例组较对照组比较无统计学意义(P＞0.05).结论 老年UAP患者存在血栓前状态,其体内存在多种止、凝血分子标记物的变化,最终可导致心肌梗死或周围血管病变发生.
目的 觀察老年不穩定型心絞痛(UAP)患者體內血液止、凝血分子標記物水平的變化併探討其臨床意義.方法 將42例老年UAP患者作為病例組,18例健康者作為對照組,分彆測定2組血清血管性血友病因子、抗凝血酶Ⅲ、纖溶酶原、血漿血小闆顆粒膜糖蛋白-140、血漿纖維蛋白原、D-二聚體含量以及血小闆膜糖蛋白分子數,併進行統計學分析.結果 病例組血小闆膜糖蛋白分子數較對照組明顯增多(P＜0.05或P＜0.01).病例組血管性血友病因子、血漿血小闆顆粒膜糖蛋白-140、血漿纖維蛋白原、D-二聚體水平較對照組明顯增加(P＜0.05或P＜0.01),而抗凝血酶Ⅲ則明顯降低(P＜0.01);纖溶酶原含量病例組較對照組比較無統計學意義(P＞0.05).結論 老年UAP患者存在血栓前狀態,其體內存在多種止、凝血分子標記物的變化,最終可導緻心肌梗死或週圍血管病變髮生.
목적 관찰노년불은정형심교통(UAP)환자체내혈액지、응혈분자표기물수평적변화병탐토기림상의의.방법 장42례노년UAP환자작위병례조,18례건강자작위대조조,분별측정2조혈청혈관성혈우병인자、항응혈매Ⅲ、섬용매원、혈장혈소판과립막당단백-140、혈장섬유단백원、D-이취체함량이급혈소판막당단백분자수,병진행통계학분석.결과 병례조혈소판막당단백분자수교대조조명현증다(P＜0.05혹P＜0.01).병례조혈관성혈우병인자、혈장혈소판과립막당단백-140、혈장섬유단백원、D-이취체수평교대조조명현증가(P＜0.05혹P＜0.01),이항응혈매Ⅲ칙명현강저(P＜0.01);섬용매원함량병례조교대조조비교무통계학의의(P＞0.05).결론 노년UAP환자존재혈전전상태,기체내존재다충지、응혈분자표기물적변화,최종가도치심기경사혹주위혈관병변발생.
Objective To observe the changes of molecular markers of blood coagulation and hemostasis in old patients with unstable angina pactoris(UAP),and to investigate the clinical significance.Methods Fourtytwo old patients with UAP were enrolled as patient group.18 volunteers were enrolled as control group.The levels of vWF,ATⅢ,Plg,GMP-140,Fbg,D-Dimer and molecular number GP were measured in both groups.Results Compared with control group,there were significant changes of molecular number GP,vWF,GMP-140,Plg,D-Dimer,ATⅢ in old patients with UAP(P＜0.05,P＜0.01).Conclusion There is pre-thrombotic state in old patients with UAP.Many factors in blood may help develop coagulation and hemostasis,resulting in myocardial infarction as well as vascular disease.
