中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2012年
4期
355-358
,共4页
钱琴%王天成%宋艳双%王丽%李钰慧%余善法%张济%马衍辉%张宁%周敬文%刘岚铮%闫蕾%贾光
錢琴%王天成%宋豔雙%王麗%李鈺慧%餘善法%張濟%馬衍輝%張寧%週敬文%劉嵐錚%閆蕾%賈光
전금%왕천성%송염쌍%왕려%리옥혜%여선법%장제%마연휘%장저%주경문%류람쟁%염뢰%가광
铬酸盐类%铬%铁%红细胞
鉻痠鹽類%鉻%鐵%紅細胞
락산염류%락%철%홍세포
Chromates%Chromium%Iron%Erythrocytes
目的 探讨铬酸盐生产场所铬、铁联合暴露对工人外周血红细胞代谢的影响及其可能机制.方法 2008年12月于济南某化工厂选择115名铬酸盐生产工人作为暴露组,选取远离工厂某小区的60名健康居民作为对照组.通过空气滤膜采样,调查各工段铬、铁的环境浓度.采集研究对象的外周血,进行全血铬、铁、铜含量(以下简称血铬、血铁、血铜)、血清中叶酸、维生素B12含量和平均红细胞血红蛋白含量(MCH)、平均红细胞体积(MCV)检测及相关性分析.结果 铬酸盐生产场所各工段空气铬浓度中位数(四分位数间距)为9.0( 10.5)μg/m3,空气铁浓度中位数(四分位数间距)为11.2(10.1)μg/m3,均高于对照组所在的居民小区[分别为0.1(0.1)、7.2(2.5) μg/m3](P值均＜0.01)；暴露组血铬含量中位数(四分位数间距)为15.5(14.1)μg/L,血铁含量为(895.1±90.2)mg/L,与对照组[分别为3 6(2.0)μg/L、(563.7 ±49.3) mg/L]相比,差异有统计学意义(P值均＜0.01)；暴露组血清叶酸、维生素B12、血铜含量分别为(6.9±2.5)、(396.4±177.0)、(777.6±103.5) μg/L,均低于对照组[分别为(558.0±330.8)、(8.1±3 8)、(812.1 ±94.6) μg/L](P值均＜ 0.05).血铬含量与血清叶酸、维生素B12含量相关(r值分别为- 0.319和- 0.293,P值均＜0.01),血铁含量与血铜含量相关(r=0.247,P＜0.01),血清维生素B12含量、血铜含量均与MCII、MCV相关(r值分别为-0.223、-0.242、-0.261、-0.292,P值均＜0.01).结论 铬酸盐生产各工段存在铬、铁的联合暴露,铬可能通过影响叶酸和维生素B12代谢、铁可能通过影响铜代谢,对机体红细胞代谢产生抑制作用.
目的 探討鉻痠鹽生產場所鉻、鐵聯閤暴露對工人外週血紅細胞代謝的影響及其可能機製.方法 2008年12月于濟南某化工廠選擇115名鉻痠鹽生產工人作為暴露組,選取遠離工廠某小區的60名健康居民作為對照組.通過空氣濾膜採樣,調查各工段鉻、鐵的環境濃度.採集研究對象的外週血,進行全血鉻、鐵、銅含量(以下簡稱血鉻、血鐵、血銅)、血清中葉痠、維生素B12含量和平均紅細胞血紅蛋白含量(MCH)、平均紅細胞體積(MCV)檢測及相關性分析.結果 鉻痠鹽生產場所各工段空氣鉻濃度中位數(四分位數間距)為9.0( 10.5)μg/m3,空氣鐵濃度中位數(四分位數間距)為11.2(10.1)μg/m3,均高于對照組所在的居民小區[分彆為0.1(0.1)、7.2(2.5) μg/m3](P值均＜0.01)；暴露組血鉻含量中位數(四分位數間距)為15.5(14.1)μg/L,血鐵含量為(895.1±90.2)mg/L,與對照組[分彆為3 6(2.0)μg/L、(563.7 ±49.3) mg/L]相比,差異有統計學意義(P值均＜0.01)；暴露組血清葉痠、維生素B12、血銅含量分彆為(6.9±2.5)、(396.4±177.0)、(777.6±103.5) μg/L,均低于對照組[分彆為(558.0±330.8)、(8.1±3 8)、(812.1 ±94.6) μg/L](P值均＜ 0.05).血鉻含量與血清葉痠、維生素B12含量相關(r值分彆為- 0.319和- 0.293,P值均＜0.01),血鐵含量與血銅含量相關(r=0.247,P＜0.01),血清維生素B12含量、血銅含量均與MCII、MCV相關(r值分彆為-0.223、-0.242、-0.261、-0.292,P值均＜0.01).結論 鉻痠鹽生產各工段存在鉻、鐵的聯閤暴露,鉻可能通過影響葉痠和維生素B12代謝、鐵可能通過影響銅代謝,對機體紅細胞代謝產生抑製作用.
목적 탐토락산염생산장소락、철연합폭로대공인외주혈홍세포대사적영향급기가능궤제.방법 2008년12월우제남모화공엄선택115명락산염생산공인작위폭로조,선취원리공엄모소구적60명건강거민작위대조조.통과공기려막채양,조사각공단락、철적배경농도.채집연구대상적외주혈,진행전혈락、철、동함량(이하간칭혈락、혈철、혈동)、혈청중협산、유생소B12함량화평균홍세포혈홍단백함량(MCH)、평균홍세포체적(MCV)검측급상관성분석.결과 락산염생산장소각공단공기락농도중위수(사분위수간거)위9.0( 10.5)μg/m3,공기철농도중위수(사분위수간거)위11.2(10.1)μg/m3,균고우대조조소재적거민소구[분별위0.1(0.1)、7.2(2.5) μg/m3](P치균＜0.01)；폭로조혈락함량중위수(사분위수간거)위15.5(14.1)μg/L,혈철함량위(895.1±90.2)mg/L,여대조조[분별위3 6(2.0)μg/L、(563.7 ±49.3) mg/L]상비,차이유통계학의의(P치균＜0.01)；폭로조혈청협산、유생소B12、혈동함량분별위(6.9±2.5)、(396.4±177.0)、(777.6±103.5) μg/L,균저우대조조[분별위(558.0±330.8)、(8.1±3 8)、(812.1 ±94.6) μg/L](P치균＜ 0.05).혈락함량여혈청협산、유생소B12함량상관(r치분별위- 0.319화- 0.293,P치균＜0.01),혈철함량여혈동함량상관(r=0.247,P＜0.01),혈청유생소B12함량、혈동함량균여MCII、MCV상관(r치분별위-0.223、-0.242、-0.261、-0.292,P치균＜0.01).결론 락산염생산각공단존재락、철적연합폭로,락가능통과영향협산화유생소B12대사、철가능통과영향동대사,대궤체홍세포대사산생억제작용.
Objective To investigate the effect of combined occupational exposure of chromium and iron on etythrocyte metabolism,and the possible mechanism.Methods A total of 115 chromate production workers were selected in a chemical factory of Jinan as exposure group,Dec.2008,and 60 healthy residents from a community which was far away from the factory were enrolled as control group.Environmental concentrations of chromium and iron were collected by filter membrane sampling and determined.The peripheral blood of subjects were collected for determination of chromium,iron,copper in whole blood and folate,vitamin B12 in serum,mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV)and correlation analysis was conducted.Results The median ( quartile interval) concentration of airchromium and air-iron in workplace were 9.0 ( 10.5 ) and 11.2 ( 10.1 ) μg/m3,respectively,which were significantly higher than that of the control (0.1 (0.1 ) and 7.2 ( 2.5 ) μg/m3 ) ( all P values ＜ 0.01 ).Bloodchromium and blood-iron of the exposed group were 15.5 ( 14.1 ) μg/L and ( 895.1 ± 90.2 ) mg/L,which were significantly higher than the counterpart of the control( 3.6 (2.0) μg/L,(563.7 ± 49.3 ) mg/L) ( all P values ＜ 0.01 ).Serum folate ( ( 6.9 ± 2.5 ) μg/L),scrum vitamin B12 ( ( 396.4 ± 177.0) μg/L) and blood copper( (777.6 ± 103.5 ) μg/L) of the exposed group were all significantly lower comparing to the control group ((558.0±330.8),(8.1 ±3.8),(812.1 ±94.6) μg/L) (all P values ＜0.05).The relationships between blood chromium and serum folate,serum vitamin B12 were statistical significant ( r =-0.319 and -0.293,P ＜ 0.01 ).Both serum vitamin B12 and blood copper correlated with mean corpuscular hemoglobin(MCH) and mean corpuscular volume (MCV) ( r =0.223,-0.242, -0.261,-0.292,all P values ＜ 0.01 ).Conclusion Combined chromium and iron exposure existed in the workplace.Adverse effect of chromium on human erythrocyte may via folate and vitamin B12 metabolism,while iron may via copper metabolism.
