CAJ | 학술논문

目的监测烟台地区肺炎链球菌的耐药性,为临床合理应用抗菌药物提供理论依据.方法收集烟台地区部分医院临床分离的肺炎链球菌,用E-试验、K-B法检测此菌对青霉素等10种抗菌药物的敏感度.结果 102株肺炎链球菌中71株(70%)对青霉素不敏感.未检出对头孢噻肟、阿莫西林、左旋氧氟沙星和万古霉素耐药的菌株.对克林霉素、红霉素、四环素和复方新诺明耐药率很高,分别为97%、100%、100%和96%.结论烟台地区青霉素不敏感肺炎链球菌检出率高,对大环内酯类药物耐药状况极为严峻.
목적 감측연태지구폐염련구균적내약성,위림상합리응용항균약물제공이론의거.방법 수집연태지구부분의원림상분리적폐염련구균,용E-시험、K-B법검측차균대청매소등10충항균약물적민감도.결과 102주폐염련구균중71주(70%)대청매소불민감.미검출대두포새우、아막서림、좌선양불사성화만고매소내약적균주.대극림매소、홍매소、사배소화복방신낙명내약솔흔고,분별위97%、100%、100%화96%.결론 연태지구청매소불민감폐염련구균검출솔고,대대배내지류약물내약상황겁위엄준.
Objective To monitor the antimicrobial resistance of streptococcus pneumoniae in Yantai area so as to provide theoretical basis for rational use of antibiotics. Methods The clinical streptococcus pneumoniae isolates were collected from some hospitals in Yantai area. E-test and K-B disk diffusion method were used to determine the susceptibility of streptococcus pneumoniae to 10 antimicrobial agents. Results Seventy-one streptococcus pneumoniae isolates(71/102, 70%) were insensitive to penicillin. None of cefotaxime-, amoxicillin- , levofloxacin-, and vancomycin-resistant strains was found. The resistance rate of streptococcus pneumoniae was relatively highly resistant to clindamyein, erythromycin, tetracycline and TMP-SMZ, 97%, 100%, 100% and 96% respectively. Conclusion Penicillin non-susceptible streptococcus pneumoniae is highly prevalent in Yantai area. The situation is serious about macrolide-resistance of streptococcus pneumoniae.