国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2010年
6期
303-305
,共3页
林路洋%杨日东%张锡宝%宋卫忠%何玉清%梁艳华%汤少开%李季%李仰琪%毕超%钟道清
林路洋%楊日東%張錫寶%宋衛忠%何玉清%樑豔華%湯少開%李季%李仰琪%畢超%鐘道清
림로양%양일동%장석보%송위충%하옥청%량염화%탕소개%리계%리앙기%필초%종도청
梅毒%神经梅毒%患病率
梅毒%神經梅毒%患病率
매독%신경매독%환병솔
Syphilis%Neurosyphilis%Prevalence
目的 探讨广州市神经梅毒流行情况,比较未经治疗隐性梅毒患者和血清固定的隐性梅毒患者中神经梅毒的患病率.方法 以横断面研究的方法,对初次诊断为隐性梅毒患者(未治疗或经治疗后出现血清固定)抽取脑脊液,进行性病研究实验室试验,筛查神经梅毒患者.结果 未经治疗隐性梅毒患者中有21.98%(60/273)为神经梅毒,其中10.99%(30/273)为无症状神经梅毒,10.99%(30/273)为有症状神经梅毒.经抗梅毒治疗血清固定隐性梅毒患者83例中1.20%(1/83)符合神经梅毒诊断,为无症状神经梅毒病例.在未经治疗隐性梅毒组中,无神经梅毒病例年龄与有神经梅毒病例年龄差异有统计学意义,前者年龄低于后者.结论 在抗梅毒治疗后产生梅毒血清固定患者神经梅毒发生的可能性相对未经治疗的隐性梅毒小,神经梅毒仍主要发生于未经治疗的潜伏梅毒人群中,提示未经治疗的隐性梅毒是神经梅毒发生的主要危险因素.
目的 探討廣州市神經梅毒流行情況,比較未經治療隱性梅毒患者和血清固定的隱性梅毒患者中神經梅毒的患病率.方法 以橫斷麵研究的方法,對初次診斷為隱性梅毒患者(未治療或經治療後齣現血清固定)抽取腦脊液,進行性病研究實驗室試驗,篩查神經梅毒患者.結果 未經治療隱性梅毒患者中有21.98%(60/273)為神經梅毒,其中10.99%(30/273)為無癥狀神經梅毒,10.99%(30/273)為有癥狀神經梅毒.經抗梅毒治療血清固定隱性梅毒患者83例中1.20%(1/83)符閤神經梅毒診斷,為無癥狀神經梅毒病例.在未經治療隱性梅毒組中,無神經梅毒病例年齡與有神經梅毒病例年齡差異有統計學意義,前者年齡低于後者.結論 在抗梅毒治療後產生梅毒血清固定患者神經梅毒髮生的可能性相對未經治療的隱性梅毒小,神經梅毒仍主要髮生于未經治療的潛伏梅毒人群中,提示未經治療的隱性梅毒是神經梅毒髮生的主要危險因素.
목적 탐토엄주시신경매독류행정황,비교미경치료은성매독환자화혈청고정적은성매독환자중신경매독적환병솔.방법 이횡단면연구적방법,대초차진단위은성매독환자(미치료혹경치료후출현혈청고정)추취뇌척액,진행성병연구실험실시험,사사신경매독환자.결과 미경치료은성매독환자중유21.98%(60/273)위신경매독,기중10.99%(30/273)위무증상신경매독,10.99%(30/273)위유증상신경매독.경항매독치료혈청고정은성매독환자83례중1.20%(1/83)부합신경매독진단,위무증상신경매독병례.재미경치료은성매독조중,무신경매독병례년령여유신경매독병례년령차이유통계학의의,전자년령저우후자.결론 재항매독치료후산생매독혈청고정환자신경매독발생적가능성상대미경치료적은성매독소,신경매독잉주요발생우미경치료적잠복매독인군중,제시미경치료적은성매독시신경매독발생적주요위험인소.
Objective To compare the prevalence of neurosyphilis in untreated patients with latent syphilis (LS) versus serofast patients treated for LS in Guangzhou City. Methods A cross-sectional study was performed. Cerebrospinal fluid was obtained from 356 patients who were first diagnosed with LS, and venereal disease research laboratory (VDRL) test was conducted to screen neurosyphilis. Results Among 273 untreated patients with LS, 60 (21.98%) were diagnosed with neurosyphilis, and of the 60 patients, 30 were asymptomatic , and the other 30 were symptomatic. In 83 serofast patients treated for LS, only 1 ( 1.2% ) was diagnosed with neurosyphilis, while no symptom was observed in this patient. In untreated cases of LS, the mean age was significantly lower in patients without neurosyphilis than in those with neurosyphilis.Conclusions Patients with untreated LS are more likely to develop neurosyphilis compared with serofast patients treated for LS, and neurosyphilis mainly occurs in untreated patients with LS, suggesting that untreated latent syphilis is an important risk factor for the development of neurosyphilis.
