CAJ | 학술논문

目的观察无创正压通气联合纳络酮治疗慢性阻塞性肺疾病( chronic obstructive pulmonary disease,COPD)合并肺性脑病的临床疗效.方法将86例COPD合并肺性脑病患者随机分为两组,对照组和治疗组,各43例.在常规治疗基础上,对照组给予无创正压通气治疗,治疗组使用无创正压通气联合纳洛酮治疗.结果治疗组在治疗后2h、48 h PCO2较治疗前明显改善(P＜0.01),治疗后2h、48 h pH、PCO2优于对照组(P＜0.05或P＜0.01).治疗组气管插管率23％,对照组为42％.结论使用无创正压通气联合纳洛酮治疗COPD肺性脑病患者,较单纯无创正压通气可以更早更有效地改善二氧化碳潴留和pH值,缩短神志恢复时间,降低气管插管率.
목적 관찰무창정압통기연합납락동치료만성조새성폐질병( chronic obstructive pulmonary disease,COPD)합병폐성뇌병적림상료효.방법 장86례COPD합병폐성뇌병환자수궤분위량조,대조조화치료조,각43례.재상규치료기출상,대조조급여무창정압통기치료,치료조사용무창정압통기연합납락동치료.결과 치료조재치료후2h、48 h PCO2교치료전명현개선(P＜0.01),치료후2h、48 h pH、PCO2우우대조조(P＜0.05혹P＜0.01).치료조기관삽관솔23％,대조조위42％.결론 사용무창정압통기연합납락동치료COPD폐성뇌병환자,교단순무창정압통기가이경조경유효지개선이양화탄저류화pH치,축단신지회복시간,강저기관삽관솔.
Objective To observe the effect of non -invasive positive pressure ventilation (NIPPV) combined with allylnoroxymorphone on chronic obstructive pulmonary disease (COPD) with pulmonary encephalopathy.Methods 86 cases of COPD patients combined with pulmonary encephalopathy were randomly divided into 2 groups,treatment group and controi group. On the basis of routine treatment,the control group was treated with NIPPV,while the treatment group was treated with NIPPV combined with allylnoroxymorphone.Results The levels PCO2 was significantly improved at 2 and 48 hours in treatment group compared to those at baseline ( P ＜0.01).The level of PCO2 and pH at 2 and 48 hours in treatment group was significantly superior to those in control group ( P ＜0.05 or P ＜0.01).The tracheal intubation rate of the treatment group was 23％,while that of the control group was 42％.Conclusions Compared with NIPPV treatment alone on COPD patients with pulmonary encephalopathy,combined NIPPV and allylnoroxymorphone treatment can improve carbon dioxide retention and the level of pH more earlier and effective,and can shorten the time of consciousness recovered,decrease the tracheal intubation rate.